Introduction: Variability of drug response is an important consideration in clinical medicine. A
major determinant of drug response variability is hepatic cytochrome P450 oxidase …

Importance of the field: The use of the first generation non-nucleoside reverse transcriptase
inhibitor efavirenz (EFV) as a component of first-line antiretroviral therapy has been …

Efavirenz is a highly effective HIV-1 antiretroviral; however, it is also frequently associated
with neuropsychiatric adverse events (NPAE) that include abnormal dreams, sleep …

Aim: Hepatic enzymes, CYP2B6 and UGT2B7 play a major role in the metabolism of the
widely used antiretroviral drugs efavirenz, nevirapine and zidovudine. In the present study …

CYP2B6 is a member of the cytochrome P450 family of important pharmacogenes and
makes up approximately 2–10% of the total hepatic CYP content [1]. CYP2B6 is also …

Abstract Background Cytochrome P450 2B6 (CYP2B6) metabolizes efavirenz and
nevirapine, the major core antiretroviral drugs for HIV in Thailand. Rifampicin, a critical …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Interindividual variability in efavirenz
plasma concentrations is associated with CYP2B6 genetic polymorphisms.• Twenty‐nine …

The aims of this ANRS12154 open-label, single-center, multiple-dose pharmacokinetic
study were to characterize nevirapine pharmacokinetics in a Cambodian population of HIV …

Methods Forty-one HIV-infected Ugandan children (3–12 years) on efavirenz+ lamivudine+
abacavir were enrolled in a study of twice-daily to once-daily lamivudine+ abacavir 36 …

2283-2296. 8. Brown TT, Cole SR, Li X, et al. Antiretroviral therapy and the prevalence and
incidence of diabetes mellitus in the multicenter AIDS cohort study. Arch Intern Med. 2005; …