The genetic background of inflammatory bowel disease: from correlation to causality

WTC Uniken Venema, MD Voskuil… - The Journal of …, 2017 - Wiley Online Library
Recent studies have greatly improved our insight into the genetic background of
inflammatory bowel disease (IBD). New high‐throughput technologies and large‐scale …

[HTML][HTML] New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function

SH Fu, LT Yeh, CC Chu, BLJ Yen, HK Sytwu - Journal of biomedical …, 2017 - Springer
B lymphocyte-induced maturation protein-1 (Blimp-1) serves as a master regulator of the
development and function of antibody-producing B cells. Given that its function in T …

Oat β-glucan alleviates DSS-induced colitis via regulating gut microbiota metabolism in mice

J Bai, J Zhao, ALA Waleed, J Wang, L Xue, J Liu… - Food & function, 2021 - pubs.rsc.org
Ulcerative colitis (UC) is one of the most prevalent inflammatory bowel diseases (IBD)
worldwide, while oat β-glucan has been shown to suppress the progress of colitis in UC …

The role of interleukin-13 in chronic inflammatory intestinal disorders

P Giuffrida, F Caprioli, F Facciotti, A Di Sabatino - Autoimmunity reviews, 2019 - Elsevier
Abstract Interleukin (IL)-13 is a cytokine playing a pivotal role in T helper (Th) 2 immune
response supposed to be implicated in some intestinal disorders. IL-13 is produced by Th2 …

[HTML][HTML] Faecalibacterium prausnitzii supernatant ameliorates dextran sulfate sodium induced colitis by regulating Th17 cell differentiation

XL Huang, X Zhang, XY Fei, ZG Chen… - World journal of …, 2016 - ncbi.nlm.nih.gov
AIM: To explore the preventive and therapeutic effects of Faecalibacterium prausnitzii (F.
prausnitzii) supernatant on dextran sulfate sodium (DSS) induced colitis in mice. METHODS …

[HTML][HTML] Interplay between cytokine circuitry and transcriptional regulation shaping helper T cell pathogenicity and plasticity in inflammatory bowel disease

SH Fu, MW Chien, CY Hsu, YW Liu… - International Journal of …, 2020 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic disorder manifested as Crohn's disease (CD)
and ulcerative colitis (UC) characterized by intestinal inflammation and involves a …

[HTML][HTML] Targeting regulatory T cells by addressing tumor necrosis factor and its receptors in allogeneic hematopoietic cell transplantation and cancer

H Wajant, A Beilhack - Frontiers in Immunology, 2019 - frontiersin.org
An intricate network of molecular and cellular actors orchestrates the delicate balance
between effector immune responses and immune tolerance. The pleiotropic cytokine tumor …

[HTML][HTML] Blimp-1 molds the epigenetic architecture of IL-21–mediated autoimmune diseases through an autoregulatory circuit

YW Liu, SH Fu, MW Chien, CY Hsu, MH Lin, JL Dong… - JCI insight, 2022 - ncbi.nlm.nih.gov
Abstract Positive regulatory domain 1 (PRDM1) encodes B lymphocyte–induced maturation
protein 1 (BLIMP1), also known as a master regulator of T cell homeostasis. We observed a …

[HTML][HTML] Mesenchymal stromal cells mitigate experimental colitis via insulin-like growth factor binding protein 7-mediated immunosuppression

Y Liao, J Lei, M Liu, W Lin, D Hong, Y Tuo, MH Jiang… - Molecular Therapy, 2016 - cell.com
Mesenchymal stromal cells (MSCs) have shown great potential for treating inflammatory
bowel disease, which is ameliorated through paracrine cross talk between MSCs and T …

Huangqin‐Tang Ameliorates TNBS‐Induced Colitis by Regulating Effector and Regulatory CD4+ T Cells

Y Zou, WY Li, Z Wan, B Zhao, ZW He… - BioMed Research …, 2015 - Wiley Online Library
Huangqin‐Tang decoction (HQT) is a classic traditional Chinese herbal formulation that is
widely used to ameliorate the symptoms of gastrointestinal disorders, including inflammatory …