Aging-related cellular, structural and functional changes in the lymph nodes: A significant component of immunosenescence? An overview
M Cakala-Jakimowicz, P Kolodziej-Wojnar… - Cells, 2021 - mdpi.com
Aging affects all tissues and organs. Aging of the immune system results in the severe
disruption of its functions, leading to an increased susceptibility to infections, an increase in …
disruption of its functions, leading to an increased susceptibility to infections, an increase in …
Lipid nanoparticles technology in vaccines: Shaping the future of prophylactic medicine
AAH Abdellatif, MA Younis, AF Alsowinea… - Colloids and Surfaces B …, 2023 - Elsevier
Throughout decades, the intrinsic power of the immune system to fight pathogens has
inspired researchers to develop techniques that enable the prevention or treatment of …
inspired researchers to develop techniques that enable the prevention or treatment of …
Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T‐cell activation
RA Rosalia, ED Quakkelaar, A Redeker… - European journal of …, 2013 - Wiley Online Library
The efficiency of antigen (A g) processing by dendritic cells (DC s) is vital for the strength of
the ensuing T‐cell responses. Previously, we and others have shown that in comparison to …
the ensuing T‐cell responses. Previously, we and others have shown that in comparison to …
[HTML][HTML] From infection to immunity: understanding the response to SARS-CoV2 through in-silico modeling
Background Immune system conditions of the patient is a key factor in COVID-19 infection
survival. A growing number of studies have focused on immunological determinants to …
survival. A growing number of studies have focused on immunological determinants to …
[图书][B] Mathematical immunology of virus infections
Understanding the cellular and molecular mechanisms that control the ability of the immune
system to mount a protective response against pathogen-derived foreign antigens, but avoid …
system to mount a protective response against pathogen-derived foreign antigens, but avoid …
Multi-compartment 3D-cultured organ-on-a-chip: towards a biomimetic lymph node for drug development
The interaction of immune cells with drugs and/or with other cell types should be
mechanistically investigated in order to reduce attrition of new drug development. However …
mechanistically investigated in order to reduce attrition of new drug development. However …
Topological small-world organization of the fibroblastic reticular cell network determines lymph node functionality
Fibroblastic reticular cells (FRCs) form the cellular scaffold of lymph nodes (LNs) and
establish distinct microenvironmental niches to provide key molecules that drive innate and …
establish distinct microenvironmental niches to provide key molecules that drive innate and …
Spatiotemporal dynamics of virus infection spreading in tissues
Virus spreading in tissues is determined by virus transport, virus multiplication in host cells
and the virus-induced immune response. Cytotoxic T cells remove infected cells with a rate …
and the virus-induced immune response. Cytotoxic T cells remove infected cells with a rate …
Multiscale modelling in immunology: a review
A Cappuccio, P Tieri, F Castiglione - Briefings in bioinformatics, 2016 - academic.oup.com
One of the greatest challenges in biomedicine is to get a unified view of observations made
from the molecular up to the organism scale. Towards this goal, multiscale models have …
from the molecular up to the organism scale. Towards this goal, multiscale models have …
SimB16: modeling induced immune system response against B16-melanoma
Immunological therapy of progressive tumors requires not only activation and expansion of
tumor specific cytotoxic T lymphocytes (CTLs), but also an efficient effector phase including …
tumor specific cytotoxic T lymphocytes (CTLs), but also an efficient effector phase including …