Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied
female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated …

Innate immunity is essential for the host against pathogens, cancer, and autoimmunity. The
innate immune system encodes many sensor, adaptor, and effector proteins and relies on …

Liquid–liquid phase separation (LLPS) is emerging as a mechanism of spatiotemporal
regulation that could answer long-standing questions about how order is achieved in …

Lipid homeostasis is essential for normal cellular functions and dysregulation of lipid
metabolism is highly correlated with human diseases including neurodegenerative …

NEMO is a ubiquitin-binding protein which regulates canonical NF-κB pathway activation in
innate immune signaling, cell death regulation and host-pathogen interactions. Here we …

Biomolecular condensates form via multivalent interactions among key macromolecules and
are regulated through ligand binding and/or posttranslational modifications. One such …

Rationale: Sepsis is a potentially life-threatening condition caused by the body's response to
a severe infection. Although the identification of multiple pathways involved in inflammation …

The inhibitor of κB (IκB) kinase (IKK) is a central regulator of NF-κB signaling. All IKK
complexes contain hetero-or homodimers of the catalytic IKKβ and/or IKKα subunits. Here …

Purinosomes serve as metabolons to enhance de novo purine synthesis (DNPS) efficiency
through compartmentalizing DNPS enzymes during stressed conditions. However, the …

The NF-κB essential modulator NEMO is the core regulatory component of the inhibitor of κB
kinase complex, which is a critical checkpoint in canonical NF-κB signaling downstream of …