Drug-induced liver injury and anti-hepatotoxic effect of herbal compounds: A metabolic mechanism perspective

J Rani, SB Dhull, PK Rose, MK Kidwai - Phytomedicine, 2024 - Elsevier
Background Drug-induced liver injury (DILI) is the most challenging and thought-provoking
liver problem for hepatologists owing to unregulated medication usage in medical practices …

Hepatoprotective and therapeutic effects of resveratrol: A focus on anti‐inflammatory and antioxidative activities

S Chupradit, D Bokov, MY Zamanian… - Fundamental & …, 2022 - Wiley Online Library
Being the most essential organ in the body, the liver performs critical functions. Hepatic
disorders, such as alcoholic liver disease, hepatic steatosis, liver fibrosis, nonalcoholic fatty …

The effects of resveratrol on inflammation and oxidative stress in a rat model of chronic obstructive pulmonary disease

XL Wang, T Li, JH Li, SY Miao, XZ Xiao - Molecules, 2017 - mdpi.com
Oxidative stress and inflammation are hypothesized to contribute to the pathogenesis of
chronic obstructive pulmonary disease (COPD). Resveratrol (trans-3, 5, 4 …

Mechanisms of isoniazid and rifampicin-induced liver injury and the effects of natural medicinal ingredients: A review

X Zhuang, L Li, T Liu, R Zhang, P Yang… - Frontiers in …, 2022 - frontiersin.org
Isoniazid (INH) and rifampicin (RFP) are the first-line medications for tuberculosis treatment,
and liver injury is the major adverse effect. Natural medicinal ingredients provide distinct …

A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives

R Domitrović, I Potočnjak - Archives of toxicology, 2016 - Springer
Hepatoprotective effects of natural compounds have been frequently attributed to their
antioxidant properties and the ability to mobilize endogenous antioxidant defense system …

[HTML][HTML] Hepatoprotective properties of oleanolic and ursolic acids in antitubercular drug-induced liver damage

GA Gutiérrez-Rebolledo, AG Siordia-Reyes… - Asian Pacific journal of …, 2016 - Elsevier
Objective To estimate to what extent the mixture of ursolic acid and oleanolic acid, in
addition to the antitubercular standard regime, affects the hepatotoxicity profile. Methods …

Protective effects of Vitis vinifera (grapes) and one of its biologically active constituents, resveratrol, against natural and chemical toxicities: A comprehensive review

J Tabeshpour, S Mehri… - Phytotherapy …, 2018 - Wiley Online Library
Vitis vinifera (grape) is one of the “most‐produced fruit” in the world. Grape seeds are a
valuable source of phenolic compounds including resveratrol (RSV). Grape and one of its …

Hepatoprotective effects of resveratrol on α-amanitin-induced liver toxicity in rats

A Gezer, H Ustundag, AS Mendil, G Bedir, L Duysak - Toxicon, 2024 - Elsevier
Objective The hepatoprotective effects of resveratrol against α-Amanitin (α-AMA)-induced
liver toxicity were investigated in an experimental rat model, focusing on oxidative stress …

[HTML][HTML] Medicinal plants: adjunct treatment to tuberculosis chemotherapy to prevent hepatic damage

N Mangwani, PK Singh, V Kumar - Journal of Ayurveda and integrative …, 2020 - Elsevier
The effectiveness of herbs for the management of chemically induced hepatotoxicity has
been discussed by many researchers. However, there is a paucity of compressive literature …

The beneficial roles of SIRT1 in drug‐induced liver injury

T Yan, J Huang, MF Nisar, C Wan… - Oxidative Medicine and …, 2019 - Wiley Online Library
Drug‐induced liver injury (DILI) is a major cause of acute liver failure (ALF) as a result of
accumulated drugs in the human body metabolized into toxic agents and helps generate …