Perineural invasion (PNI) is a possible route for metastatic spread in various cancer types,
including colorectal cancer (CRC). PNI is linked to poor prognosis, but systematic analyses …

Simple Summary The results of tumor budding are an independent prognostic factor of
locoregional recurrences in many solid cancers, including colorectal, nasopharyngeal …

Risk evaluation of lymph node metastasis (LNM) for endoscopically resected submucosal
invasive (T1) colorectal cancers (CRC) is critical for determining therapeutic strategies, but …

Poor histological differentiation is currently considered among the adverse histopathological
factors associated with unfavourable clinical course of colorectal carcinoma (CRC). At …

Context.—Tumor budding has received increasing recognition as an important independent
prognostic factor in colorectal carcinoma. Prominent tumor budding in adenocarcinoma …

Tumor staging according to the American Joint Committee on Cancer/Union for International
Cancer Control tumor, node, metastasis (TNM) system is currently regarded as the standard …

Poorly differentiated clusters (PDC), defined as small groups of≥ 5 tumour cells without
glandular differentiation, have gained recent attention as a promising prognostic factor in …

Head and neck squamous cell carcinoma forms an anatomically and functionally complex
group of malignancies. The significant local aggressiveness and frequent regional relapses …

Morphological features including infiltrative growth, tumour budding (TB), and poorly
differentiated clusters (PDCs) have a firmly established negative predictive value in …

Introduction: Intratumoral heterogeneity implies the existence of differences between tumor
cells, which can best be shown by histochemical and immunohistochemical techniques. The …