Uncontrolled regulation of specific metalloenzymes plays important roles in several
diseases like tumor metastasis and inflammation. Therefore, selective metalloenzyme …

Human deaths caused by Gram-negative bacteria keep rising due to the multidrug
resistance (MDR) phenomenon. Therefore, it is a priority to develop novel antibiotics with …

The increasing emergence of antibiotic resistance necessitates the development of anti-
infectives with novel modes of action. Targeting bacterial virulence is considered a …

In search of novel antibiotics to combat the challenging spread of resistant pathogens,
bacterial proteases represent promising targets for pathoblocker development. A common …

Aliphatic hydroxamic acids (HA) with varying numbers of carbon atoms, C2, C6, C8, C10,
C12 and C17, and corresponding Fe (II), Fe (III), Ni (II), Cu (II) and Zn (II) complexes have …

Compounds containg catechol or bisphosphonate were tested as inhibitors of the zinc
metalloproteases, thermolysin (TLN), pseudolysin (PLN) and aureolysin (ALN) which are …

ABSTRACT Matrix metalloproteinase-2 (MMP-2) is a lucrative therapeutic target as far as
anticancer drug discovery is concerned. Overexpression of MMP-2 is found to facilitate …

Inhibitors targeting bacterial enzymes should not interfere with enzymes of the host, and
knowledge about structural determinants for selectivity is important for designing inhibitors …

Zinc-dependent ADAM17 takes part in a number of life-threatening conditions such as
inflammatory diseases, cancer, Alzheimer's disease and rheumatoid arthritis. Therefore …

Bacterial multi-drug resistance is a major health problem worldwide. Inhibition of bacterial
virulence is suggested to be a promising strategy in the development of new antibacterial …