A review of existing and emerging digital technologies to combat the global trade in fake medicines

TK Mackey, G Nayyar - Expert opinion on drug safety, 2017 - Taylor & Francis
Introduction: The globalization of the pharmaceutical supply chain has introduced new
challenges, chief among them, fighting the international criminal trade in fake medicines. As …

Comprehensive comparative effectiveness and safety of first-line antihypertensive drug classes: a systematic, multinational, large-scale analysis

MA Suchard, MJ Schuemie, HM Krumholz, SC You… - The Lancet, 2019 - thelancet.com
Background Uncertainty remains about the optimal monotherapy for hypertension, with
current guidelines recommending any primary agent among the first-line drug classes …

Machine learning on adverse drug reactions for pharmacovigilance

CY Lee, YPP Chen - Drug discovery today, 2019 - Elsevier
An adverse drug reaction (ADR) is an unintended response to a drug that is noxious and the
reaction has a causal relationship to the drug 1, 2, 3, 4, 5. It is disturbing that∼ 3.6% of all …

Association of ticagrelor vs clopidogrel with net adverse clinical events in patients with acute coronary syndrome undergoing percutaneous coronary intervention

SC You, Y Rho, B Bikdeli, J Kim, A Siapos, J Weaver… - Jama, 2020 - jamanetwork.com
Importance Current guidelines recommend ticagrelor as the preferred P2Y12 platelet
inhibitor for patients with acute coronary syndrome (ACS), primarily based on a single large …

Comparative first-line effectiveness and safety of ACE (angiotensin-converting enzyme) inhibitors and angiotensin receptor blockers: a multinational cohort study

RJ Chen, MA Suchard, HM Krumholz, MJ Schuemie… - …, 2021 - Am Heart Assoc
ACE (angiotensin-converting enzyme) inhibitors and angiotensin receptor blockers (ARBs)
are equally guideline-recommended first-line treatments for hypertension, yet few head-to …

Safety of hydroxychloroquine, alone and in combination with azithromycin, in light of rapid wide-spread use for COVID-19: a multinational, network cohort and self …

JCE Lane, J Weaver, K Kostka, T Duarte-Salles… - MedRxiv, 2020 - medrxiv.org
Background Hydroxychloroquine has recently received Emergency Use Authorization by the
FDA and is currently prescribed in combination with azithromycin for COVID-19 pneumonia …

Renin–angiotensin system blockers and susceptibility to COVID-19: an international, open science, cohort analysis

DR Morales, MM Conover, SC You, N Pratt… - The Lancet Digital …, 2021 - thelancet.com
Background Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor
blockers (ARBs) have been postulated to affect susceptibility to COVID-19. Observational …

Comparative effectiveness and safety between apixaban, dabigatran, edoxaban, and rivaroxaban among patients with atrial fibrillation: a multinational population …

WCY Lau, CO Torre, KKC Man, HM Stewart… - Annals of Internal …, 2022 - acpjournals.org
Background: Current guidelines recommend using direct oral anticoagulants (DOACs) over
warfarin in patients with atrial fibrillation (AF), but head-to-head trial data do not exist to …

Association between proton pump inhibitor use and gastric cancer: a population-based cohort study using two different types of nationwide databases in Korea

SI Seo, CH Park, SC You, JY Kim, KJ Lee, J Kim, Y Kim… - Gut, 2021 - gut.bmj.com
Objective The association between proton pump inhibitor (PPI) use and gastric cancer
related to Helicobacter pylori eradication has not been fully investigated in geographical …

Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study

JCE Lane, J Weaver, K Kostka… - The Lancet …, 2020 - thelancet.com
Background Hydroxychloroquine, a drug commonly used in the treatment of rheumatoid
arthritis, has received much negative publicity for adverse events associated with its …