Traumatic brain injuries: pathophysiology and potential therapeutic targets

SY Ng, AYW Lee - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality
amongst civilians and military personnel globally. Despite advances in our knowledge of the …

Targeting tumor necrosis factor alpha for Alzheimer's disease

B Decourt, DK Lahiri… - Current Alzheimer …, 2017 - ingentaconnect.com
Alzheimer's disease (AD) affects an estimated 44 million individuals worldwide, yet no
therapeutic intervention is available to stop the progression of the dementia …

Minocycline: far beyond an antibiotic

N Garrido‐Mesa, A Zarzuelo… - British journal of …, 2013 - Wiley Online Library
Minocycline is a second‐generation, semi‐synthetic tetracycline that has been in therapeutic
use for over 30 years because of its antibiotic properties against both gram‐positive and …

Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

JA Smith, A Das, SK Ray, NL Banik - Brain research bulletin, 2012 - Elsevier
Microglia are activated in response to a number of different pathological states within the
CNS including injury, ischemia, and infection. Microglial activation results in their production …

Alzheimer's disease: clinical trials and drug development

F Mangialasche, A Solomon, B Winblad… - The Lancet …, 2010 - thelancet.com
Alzheimer's disease is the most common cause of dementia in elderly people. Research into
Alzheimer's disease therapy has been at least partly successful in terms of developing …

Neuroinflammation and Alzheimer's disease: implications for microglial activation

F Regen, J Hellmann-Regen… - Current Alzheimer …, 2017 - ingentaconnect.com
Background: Microglial activation is a hallmark of neuroinflammation, seen in most acute
and chronic neuropsychiatric conditions. With growing knowledge about microglia functions …

Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation

M Jazvinšćak Jembrek, PR Hof… - Oxidative medicine and …, 2015 - Wiley Online Library
Alzheimer's disease (AD), the most common chronic and progressive neurodegenerative
disorder, is characterized by extracellular deposits of amyloid β‐peptides (Aβ) and …

Herpes simplex virus type 1 and other pathogens are key causative factors in sporadic Alzheimer's disease

SA Harris, EA Harris - Journal of Alzheimer's Disease, 2015 - content.iospress.com
This review focuses on research in epidemiology, neuropathology, molecular biology, and
genetics regarding the hypothesis that pathogens interact with susceptibility genes and are …

The link between chronic pain and Alzheimer's disease

S Cao, DW Fisher, T Yu, H Dong - Journal of neuroinflammation, 2019 - Springer
Chronic pain often occurs in the elderly, particularly in the patients with neurodegenerative
disorders such as Alzheimer's disease (AD). Although studies indicate that chronic pain …

Natural products as a source of Alzheimer's drug leads

P Williams, A Sorribas, MJR Howes - Natural product reports, 2011 - pubs.rsc.org
Covering: up to 2010 This review focuses on recent developments in the use of natural
products as therapeutics for Alzheimer's disease. The compounds span a diverse array of …