Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and
rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic …

The transcriptional regulator STAT3 has key roles in vertebrate development and mature
tissue function including control of inflammation and immunity. Mutations in human STAT3 …

IL-6 is a pleiotropic cytokine with broad-ranging effects within the integrated immune
response. One of the roles of IL-6 is to support immunocompetence, defined as the ability of …

Acidic activation domains are intrinsically disordered regions of the transcription factors that
bind coactivators. The intrinsic disorder and low evolutionary conservation of activation …

Background In 2014, germline signal transducer and activator of transcription (STAT) 3 gain-
of-function (GOF) mutations were first described to cause a novel multisystem disease of …

Using whole-exome sequencing to examine the genetic causes of immune deficiency in 235
common variable immunodeficiency (CVID) patients seen in the United States (Mount Sinai …

Background Signal transducer and activator of transcription 3 (STAT3) gain-of-function
(GOF) germline mutations have been recently described. A comprehensive overview of this …

Skeletal deformities are typical AD-HIES manifestations, which are mainly caused by
heterozygous and loss-of-function mutations in Signal transducer and activator of …

The hyper-IgE syndromes (HIES) are a heterogeneous group of inborn errors of immunity
sharing manifestations including increased infection susceptibility, eczema, and raised …

The JAK/STAT signaling pathway plays a key role in cytokine signaling and is involved in
development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT …