Human mesenchymal stromal cell (hMSC) secretomes have shown to influence the
microenvironment upon injury, promoting cytoprotection, angiogenesis, and tissue repair …

The unperturbed lung is highly quiescent, with a remarkably low level of cell turnover.
However, once damaged, the lung shows an extensive regenerative capacity, with resident …

Preclinical models and emerging translational data suggest that acute kidney injury (AKI)
has far reaching effects on all other major organ systems in the body. Common in critically ill …

A thorough understanding of epigenetics regulatory mechanisms of premature ovarian
failure (POF) is still lacking. Here, we found that cyclophosphamide induced significantly …

Acute lung injury (ALI) induced by paraquat (PQ) progresses rapidly with high mortality;
however, there is no effective treatment, and the specific mechanism is not well understood …

Perinatal Asphyxia (PA) is a leading cause of motor and neuropsychiatric disability
associated with sustained oxidative stress, neuroinflammation, and cell death, affecting …

Klotho expression abnormalities induces kidney injury and chronic kidney disease,
however, the underlying mechanism remains unclear. Here, Klotho+/-mice and wild-type …

Idiopathic pulmonary fibrosis (IPF) has been widely accepted as an aging-related fatal lung
disease with a therapeutic impasse, largely a consequence of the complex and polygenic …

Hyperoxia-induced lung injury occurs in neonates on oxygen support due to premature birth,
often leading to the development of bronchopulmonary dysplasia. Current treatment options …

α-klotho (KL) is an anti-aging protein and has been shown to exert anti-inflammatory and
anti-oxidative effects in the lung and pulmonary diseases such as chronic obstructive …