Protecting the functional mass of insulin-producing β cells of the pancreas is a major
therapeutic challenge in patients with type 1 (T1DM) or type 2 diabetes mellitus (T2DM). The …

Islets isolated from multiple pancreas donors are often necessary to achieve euglycemia in
type 1 diabetic patients treated by islet allotransplantation. This increases the burden on the …

Human islet expansion in monolayer culture leads to loss of function and senescence. By
maintaining the 3-D configuration of islets in fibrin gels, it is feasible to expand β-cells in …

Islet transplantation is associated with a high rate of early graft failure caused by early
immune attack and poor functionality of islets. Apoptosis of islet cells appears soon after islet …

Conclusion More sensitive and reliable islet viability and potency tests have been recently
developed and tested. Those evaluating mitochondrial function are most promising …

Methods. Hand-picked, freshly isolated IHPI were incubated with PIC and estradiol. Viability
was analyzed from single islet cells stained with ethidium bromide and acridine orange …

Apoptotic cell death is a defined pathway for islet cell demise, and mitochondrial dysfunction
contributes to islet cell apoptosis. The hypothesis that the novel peptide d-Arg-2′, 6 …

The transplantation of allogeneic islets in recent clinical trials has shown substantial promise
as a therapy for type 1 diabetes; however, long-term insulin independence remains …

Early graft failure following intraportal islet transplantation (IPIT) represents a major obstacle
for successful islet transplantation. Here, we examined the role of islet emboli in the …

The rate of oxygen consumption is an important measure of mitochondrial function in all
aerobic cells. In pancreatic beta cells, it is linked to the transduction mechanism that …