The antiviral benefit of antibodies can be compromised by viral escape especially for rapidly
evolving viruses. Therefore, durable, effective antibodies must be both broad and potent to …

The SARS-CoV-2 virus responsible for the COVID-19 global pandemic has exhibited a
striking capacity for viral evolution that drives continued evasion from vaccine and infection …

Next generation sequencing of B cell receptor (BCR) repertoires has become a ubiquitous
tool for understanding the antibody-mediated immune response: it is now common to have …

A cure for HIV-1 (HIV) remains unrealized due to a reservoir of latently infected cells that
persist during antiretroviral therapy (ART), with reservoir size associated with adverse health …

Understanding the antibody response is critical to developing vaccine and antibody-based
therapies and has inspired the recent development of new methods to isolate antibodies …

Human natural history and vaccine studies support a protective role of antibody dependent
cellular cytotoxicity (ADCC) activity against many infectious diseases. One setting where this …

Blocking Plasmodium, the causative agent of malaria, at the asymptomatic pre-erythrocytic
stage would abrogate disease pathology and prevent transmission. However, the lack of …

The development of a maternal HIV vaccine to synergize with current antiretroviral drug
prophylaxis can overcome implementation challenges and further reduce mother-to-child …

The antibodies with different effector functions evoked by Human Immunodeficiency Virus
type 1 (HIV-1) transmitted from mother to child, and their role in the pathogenesis of infected …

Despite significant advances in scientific research and the advent of treatment and
prevention strategies over the past several decades, the HIV/AIDS pandemic continues to …