Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

Cyclic nucleotide phosphodiesterases (PDEs) modulate the neurohormonal regulation of
cardiac function by degrading cAMP and cGMP. In cardiomyocytes, multiple PDE isozymes …

The phosphodiesterase (PDE) enzymes, key regulator of the cyclic nucleotide signal
transduction system, are long-established as attractive therapeutic targets. During …

3', 5'-cyclic adenosine monophosphate (cAMP) mediates the effects of sympathetic
stimulation on the rate and strength of cardiac contraction. Beyond this pivotal role, in …

Phosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides,
including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate …

CFTR (cystic fibrosis transmembrane conductance regulator) is a tightly regulated anion
channel that mediates chloride and bicarbonate conductance in many epithelia and in other …

While a congestive heart failure patient will ultimately need an assist device or even a
replacement heart as the disease progresses, not every patient is qualified for such …

In the last 30 years, the field of cyclic adenosine 3′, 5′-monophosphate (cAMP) signalling
has witnessed a transformative development with the realization that cAMP is …

Abstract Phosphodiesterase 1 (PDE1) is an enzyme entrusted with the hydrolysis of the
second messengers cAMP and cGMP, thereby governing a plethora of metabolic processes …

Phosphodiesterases regulate levels of the cyclic nucleotides cyclic adenosine
monophosphate and cyclic guanosine monophosphate. Thanks to regulation by specific …