Antibiotic-loaded polymethylmethacrylate beads and spacers in treatment of orthopedic infections and the role of biofilm formation

TAG Van Vugt, JJ Arts, JAP Geurts - Frontiers in microbiology, 2019 - frontiersin.org
Polymethylmethacrylate (PMMA) also referred as (acrylic) bone cement is a non-degradable
biomaterial that has been used in clinical orthopedic practice for several decades. PMMA …

Implant materials and prosthetic joint infection: the battle with the biofilm

DJ Davidson, D Spratt, AD Liddle - EFORT open reviews, 2019 - eor.bioscientifica.com
Prosthetic joint infection (PJI) is associated with poor clinical outcomes and is expensive to
treat. Although uncommon overall (affecting between 0.5% and 2.2% of cases), PJI is one of …

Layered Double Hydroxide Modified Bone Cement Promoting Osseointegration via Multiple Osteogenic Signal Pathways

Y Wang, S Shen, T Hu, GR Williams, Y Bian, B Feng… - ACS …, 2021 - ACS Publications
Poly (methyl methacrylate)(PMMA) bone cement has been widely used in orthopedic
surgeries including total hip/knee replacement, vertebral compression fracture treatment …

Local antibiotic delivery options in prosthetic joint infection

W Steadman, PR Chapman, M Schuetz, B Schmutz… - Antibiotics, 2023 - mdpi.com
Prosthetic Joint Infection (PJI) causes significant morbidity and mortality for patients globally.
Delivery of antibiotics to the site of infection has potential to improve the treatment outcomes …

Single-or two-stage revision for infected total hip arthroplasty? A systematic review of the literature

HAC Leonard, AD Liddle, O Burke, DW Murray… - … and Related Research®, 2014 - Springer
Background The best approach for surgical treatment of an infected THA remains
controversial. Two-stage revision is believed to result in lower reinfection rates but may …

[HTML][HTML] Bactericidal coating to prevent early and delayed implant-related infections

F Jahanmard, M Croes, M Castilho, A Majed… - Journal of Controlled …, 2020 - Elsevier
The occurrence of an implant-associated infection (IAI) with the formation of a persisting
bacterial biofilm remains a major risk following orthopedic biomaterial implantation. Yet …

Applications of halloysite in tissue engineering

E Gkouma, E Gianni, K Avgoustakis, D Papoulis - Applied Clay Science, 2021 - Elsevier
Halloysite is an aluminosilicate mineral, with characteristic tubular morphology, that has
been widely used in several pharmaceutical applications. This review study is focusing on …

Composite Bone Cements with Enhanced Drug Elution

K Cherednichenko, A Sayfutdinova, D Rimashevskiy… - Polymers, 2023 - mdpi.com
Antibiotic-loaded bone cement (ALBC) has become an indispensable material in orthopedic
surgery in recent decades, owing to the possibility of drugs delivery to the surgical site. It is …

Acute kidney injury when treating periprosthetic joint infections after total knee arthroplasties with antibiotic-loaded spacers: incidence, risks, and outcomes

L Dagneaux, AK Limberg, DR Osmon, N Leung… - JBJS, 2021 - journals.lww.com
Background: Two-stage exchange arthroplasty with a high-dose antibiotic-loaded bone
cement (ALBC) spacer and intravenous or oral antibiotics is the most common method of …

The infected total hip arthroplasty

SA León, XY Mei, PR Kuzyk - Evidence‐Based Orthopedics, 2021 - Wiley Online Library
This chapter presents a case scenario of a 59‐year‐old female who is one year out from
revision of a left total hip arthroplasty (THA) due to recurrent dislocation. Periprosthetic joint …