Spin hyperpolarization in modern magnetic resonance

J Eills, D Budker, S Cavagnero, EY Chekmenev… - Chemical …, 2023 - ACS Publications
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …

In-cell NMR: Why and how?

FX Theillet, E Luchinat - Progress in Nuclear Magnetic Resonance …, 2022 - Elsevier
NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

Instrumentation for hydrogenative parahydrogen-based hyperpolarization techniques

AB Schmidt, CR Bowers, K Buckenmaier… - Analytical …, 2022 - ACS Publications
The unique properties of the entangled, antisymmetric nuclear spin state of dihydrogen,
parahydrogen (pH2), has intrigued physicists, chemists, and other scientists for almost a …

Temperature Cycling Enables Efficient 13C SABRE-SHEATH Hyperpolarization and Imaging of [1-13C]-Pyruvate

P TomHon, M Abdulmojeed, I Adelabu… - Journal of the …, 2021 - ACS Publications
Molecular metabolic imaging in humans is dominated by positron emission tomography
(PET). An emerging nonionizing alternative is hyperpolarized MRI of 13C-pyruvate, which is …

Rapid hyperpolarization and purification of the metabolite fumarate in aqueous solution

S Knecht, JW Blanchard, D Barskiy… - Proceedings of the …, 2021 - National Acad Sciences
Hyperpolarized fumarate is a promising biosensor for carbon-13 magnetic resonance
metabolic imaging. Such molecular imaging applications require nuclear hyperpolarization …

trans-Hydrogenation, gem-Hydrogenation, and trans-Hydrometalation of Alkynes: An Interim Report on an Unorthodox Reactivity Paradigm

A Fürstner - Journal of the American Chemical Society, 2018 - ACS Publications
cis-Delivery of H2 to the π-system of an unsaturated substrate is the canonical course of
metal catalyzed hydrogenation reactions. The semireduction of internal alkynes with the aid …

Recent advances in the application of parahydrogen in catalysis and biochemistry

G Buntkowsky, F Theiss, J Lins, YA Miloslavina… - RSC …, 2022 - pubs.rsc.org
Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI)
are analytical and diagnostic tools that are essential for a very broad field of applications …

Parahydrogen-Polarized Fumarate for Preclinical in Vivo Metabolic Magnetic Resonance Imaging

M Gierse, L Nagel, M Keim, S Lucas… - Journal of the …, 2023 - ACS Publications
We present a versatile method for the preparation of hyperpolarized [1-13C] fumarate as a
contrast agent for preclinical in vivo MRI, using parahydrogen-induced polarization (PHIP) …

Heterogeneous Catalysis and Parahydrogen‐Induced Polarization

EV Pokochueva, DB Burueva, OG Salnikov… - …, 2021 - Wiley Online Library
Parahydrogen‐induced polarization with heterogeneous catalysts (HET‐PHIP) has been a
subject of extensive research in the last decade since its first observation in 2007. While …

Hydrogenative-PHIP polarized metabolites for biological studies

F Reineri, E Cavallari, C Carrera, S Aime - Magnetic Resonance Materials …, 2021 - Springer
ParaHydrogen induced polarization (PHIP) is an efficient and cost-effective
hyperpolarization method, but its application to biological investigations has been …