Clonal haematopoiesis and dysregulation of the immune system
Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …
Inflammation-induced tumorigenesis and metastasis
S Hibino, T Kawazoe, H Kasahara, S Itoh… - International journal of …, 2021 - mdpi.com
Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host
M Meisel, R Hinterleitner, A Pacis, L Chen, ZM Earley… - Nature, 2018 - nature.com
Somatic mutations in te t methylcytosine dioxygenase 2 (TET2), which encodes an
epigenetic modifier enzyme, drive the development of haematopoietic malignancies,,,,,–. In …
epigenetic modifier enzyme, drive the development of haematopoietic malignancies,,,,,–. In …
Inhibition of inflammatory signaling in Tet2 mutant preleukemic cells mitigates stress-induced abnormalities and clonal hematopoiesis
Inflammation is a risk factor for cancer development. Individuals with preleukemic TET2
mutations manifest clonal hematopoiesis and are at a higher risk of developing leukemia …
mutations manifest clonal hematopoiesis and are at a higher risk of developing leukemia …
Emergency granulopoiesis
MG Manz, S Boettcher - Nature Reviews Immunology, 2014 - nature.com
Neutrophils are a key cell type of the innate immune system. They are short-lived and need
to be continuously generated in steady-state conditions from haematopoietic stem and …
to be continuously generated in steady-state conditions from haematopoietic stem and …
The central role of inflammatory signaling in the pathogenesis of myelodysplastic syndromes
DA Sallman, A List - Blood, The Journal of the American Society …, 2019 - ashpublications.org
In cancer biology, tumor-promoting inflammation and an inflammatory microenvironment
play a vital role in disease pathogenesis. In the past decade, aberrant innate immune …
play a vital role in disease pathogenesis. In the past decade, aberrant innate immune …
Clonal hematopoiesis: Mutation-specific adaptation to environmental change
MA Florez, BT Tran, TK Wathan, J DeGregori… - Cell Stem Cell, 2022 - cell.com
Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion
of genetically variant hematopoietic cells that increases exponentially with age and is …
of genetically variant hematopoietic cells that increases exponentially with age and is …
DDX41 is required for cGAS-STING activation against DNA virus infection
Upon binding double-stranded DNA (dsDNA), cyclic GMP-AMP synthase (cGAS) is activated
and initiates the cGAS-stimulator of IFN genes (STING)-type I interferon pathway. DEAD-box …
and initiates the cGAS-stimulator of IFN genes (STING)-type I interferon pathway. DEAD-box …
Pathogen-induced TLR4-TRIF innate immune signaling in hematopoietic stem cells promotes proliferation but reduces competitive fitness
Bacterial infection leads to consumption of short-lived innate immune effector cells, which
then need to be replenished from hematopoietic stem and progenitor cells (HSPCs). HSPCs …
then need to be replenished from hematopoietic stem and progenitor cells (HSPCs). HSPCs …
U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies
Spliceosome mutations are common in myelodysplastic syndromes (MDS) and acute
myeloid leukaemia (AML), but the oncogenic changes due to these mutations have not been …
myeloid leukaemia (AML), but the oncogenic changes due to these mutations have not been …