This review aims at juxtaposing common versus distinct structural and functional strategies
that are applied by aptamers, riboswitches, and ribozymes/DNAzymes. Focusing on recently …

RNA is becoming more important as an increasing number of functions, both regulatory and
enzymatic, are being discovered on a daily basis. As the RNA boom has just begun, most …

O-Methyl (Nm) is a highly abundant post-transcriptional RNA modification that plays
important biological roles through mechanisms that are not entirely understood. There is …

An ever‐increasing number of functional RNAs require a mechanistic understanding. RNA
function relies on changes in its structure, so‐called dynamics. To reveal dynamic processes …

NH groups in proteins or nucleic acids are the most challenging target for chemical shift
prediction. Here we show that the RNA base pair triplet motif dictates imino chemical shifts in …

Proteins and nucleic acids are highly dynamic bio-molecules that can populate a variety of
conformational states. NMR relaxation dispersion (RD) methods are uniquely suited to …

S-adenosylmethionine (SAM) is a central metabolite since it is used as a methyl group donor
in many different biochemical reactions. Many bacteria control intracellular SAM …

Recent studies have shown that RNAs exist in dynamic equilibrium with short-lived low-
abundance 'excited states' that form by reshuffling base pairs in and around non-canonical …

The knowledge of structure and dynamics is crucial to explain the function of RNAs. While
nuclear magnetic resonance (NMR) is well suited to probe these for complex biomolecules …

The structure of the DNA duplex is arguably one of the most important biological structures
elucidated in modern history. DNA duplex structure is closely associated with essential …