Myelinated nerve fibers are essential for the rapid propagation of action potentials by
saltatory conduction. They form as the result of reciprocal interactions between axons and …

Peripheral nerves contain large myelinated and small unmyelinated (Remak) fibers that
perform different functions. The choice to myelinate or not is dictated to Schwann cells by the …

Basement membranes are sheet-like cell-adherent extracellular matrices that serve as cell
substrata and solidphase agonists, contributing to tissue organization, stability and …

Neuromuscular disorders are often caused by heterogeneous mutations in large, structurally
complex genes. Targeting compensatory modifier genes could be beneficial to improve …

Myelination is essential for nervous system function. Schwann cells interact with neurons
and the basal lamina to myelinate axons using known receptors, signals and transcription …

Basement membranes are cell surface associated extracellular matrices containing
laminins, type IV collagens, nidogens, perlecan, agrin, and other macromolecules …

The fundamental roles of Schwann cells during peripheral nerve formation and regeneration
have been recognized for more than 100 years, but the cellular and molecular mechanisms …

Peripheral human nerves fail to regenerate across longer tube implants (> 2cm), most likely
because implants lack the microarchitecture of native nerves, including bands of Büngner …

Peripheral demyelinating diseases entail damage to axons and Schwann cells in the
peripheral nervous system. Because of poor prognosis and lack of a cure, this group of …

Schwann cell (SC) myelination in the peripheral nervous system is essential for motor
function, and uncontrolled SC proliferation occurs in cancer. Here, we show that a dual role …