Understanding the neural substrates of depression is crucial for diagnosis and treatment.
Here, we review recent studies of functional and effective connectivity in depression, in …

From the vulnerability perspective, we often ask the question “why someone suffers from
depression?” Despite outstanding achievements along this line, we still face high …

The μ-opioid receptor (MOR) system, well known for dampening physical pain, is also
hypothesized to dampen 'social pain.'We used positron emission tomography scanning with …

Background There is well-known heterogeneity in affective mechanisms in depression that
may extend to positive affect. We used data-driven parsing of neural connectivity to reveal …

Selective serotonin reuptake inhibitors (SSRIs) constitute a first-line antidepressant
intervention, though the precise cognitive and computational mechanisms that explain …

Past research has found that solution-focused (SF) coaching questions led to more positive
outcomes than problem-focused (PF) coaching questions. Another body of research …

Anhedonia, or reward system dysfunction, is associated with poorer treatment outcomes
among depressed individuals. The role of anhedonia in treatment engagement, however …

Background Intravenous (IV) ketamine has emerged as a rapid and effective treatment for
TRD. However, the specific neural mechanisms of ketamine's effects in humans remains …

The mental health of an increasing ageing population is an important part of healthcare.
Research has explored means to enrich the lives of older adults living in residential settings …

The natural time course of mood includes both acute responses to stimuli and spontaneous
fluctuations. To date, neuroimaging studies have focused on either acute affective …