Although immune checkpoint inhibitors (ICIs) that target programmed cell death protein-
1/programmed cell death ligand-1 axis have significantly shifted the treatment paradigm in …

Simple Summary Although the incorporation of immune checkpoint inhibitors (ICIs) in
melanoma treatment has significantly improved prognosis for patients with advanced …

Melanoma is the most aggressive form of skin cancer, representing approximately 4% of all
cutaneous neoplasms it accounts for up to 80% of deaths. Advanced stages of melanoma …

The proportions and phenotypes of immune cell subsets in peripheral blood undergo
continual and dramatic remodeling throughout the human life span, which complicates …

Purpose: Neoadjuvant immunotherapy may improve the clinical outcome of regionally
advanced operable melanoma and allows for rapid clinical and pathologic assessment of …

Invasive cutaneous melanoma is the most lethal skin cancer, but fortunately, the vast
majority can be surgically treated with wide local excision, and sometimes additionally with …

Advances in immunotherapy, including immune checkpoint inhibitors (ICIs), have
transformed the standard of care for many types of cancer including melanoma. ICIs have …

Purpose To evaluate the role and landscape of 5-10-Methylenetetrahydrofolate reductase
(MTHFR) to immune infiltration, tumor microenvironment, heterogeneity, immune …

Immune checkpoint inhibitors (ICIs) have dramatically transformed oncology by prolonging
overall survival and yielding better patient tolerance compared to other chemotherapeutic …

Tamoxifen (TAM) resistance is finally developed in over 40% of patients with estrogen
receptor α‐positive breast cancer (ERα+‐BC), documenting that discovering new molecular …