Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted
pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative …

Similarities in neocortical circuit organization across areas and species suggest a common
strategy to process diverse types of information, including sensation from diverse modalities …

Activity in motor cortex predicts specific movements seconds before they occur, but how this
preparatory activity relates to upcoming movements is obscure. We dissected the conversion …

Perceptual decisions involve distributed cortical activity. Does information flow sequentially
from one cortical area to another, or do networks of interconnected areas contribute at the …

Corticostriatal projections are essential components of forebrain circuits and are widely
involved in motivated behaviour. These axonal projections are formed by two distinct …

Memories are acquired and encoded within large-scale neuronal networks spanning
different brain areas. The anatomical and functional specificity of such long-range …

GABAergic interneurons play a major role in the function of the mammalian neocortex, but
their circuit connectivity is still poorly understood. We used two-photon RuBi-Glutamate …

Reciprocal interactions between the prefrontal cortex (PFC) and thalamus play a critical role
in cognition, but the underlying circuits remain poorly understood. Here we use optogenetics …

Long-range projections from the frontal cortex are known to modulate sensory processing in
multiple modalities. Although the mouse has become an increasingly important animal …

Higher-order executive tasks such as learning, working memory, and behavioral flexibility
depend on the prefrontal cortex (PFC), the brain region most elaborated in primates. The …