Obesity as a risk factor for COVID-19: an overview

RW Alberca, LM Oliveira, ACCC Branco… - Critical reviews in …, 2021 - Taylor & Francis
The current coronavirus disease-2019 (COVID-19) pandemic presents a huge challenge for
health-care systems worldwide. Many different risk factors are associated with disease …

Obesity-mediated immune modulation: one step forward,(Th) 2 steps back

V Schmidt, AE Hogan, PG Fallon… - Frontiers in …, 2022 - frontiersin.org
Over the past decades, the relationship between the immune system and metabolism has
become a major research focus. In this arena of immunometabolism the capacity of adipose …

High fat diet induced obesity model using four strains of mice: Kunming, C57BL/6, BALB/c and ICR

J Li, H Wu, Y Liu, L Yang - Experimental animals, 2020 - jstage.jst.go.jp
High fat diet (HFD) treated mouse is widely used as experimental animal model for
hyperlipidemia and hyperglycemia study. Many factors contribute to establish animal model …

Glucagon‐like peptide‐1 receptor agonist inhibits aeroallergen‐induced activation of ILC2 and neutrophilic airway inflammation in obese mice

S Toki, DC Newcomb, RL Printz, KN Cahill, KL Boyd… - Allergy, 2021 - Wiley Online Library
Background Obesity is a risk factor for the development of asthma. However, pharmacologic
therapeutic strategies that specifically target obese asthmatics have not been identified. We …

The effects of obesity in asthma

A Mohan, J Grace, BR Wang, N Lugogo - Current allergy and asthma …, 2019 - Springer
Abstract Purpose of Review Rising costs and increasing morbidity makes the identification
and treatment of high-risk asthma phenotypes important. In this review, we outline the …

Obesity alters immunopathology in cancers and inflammatory diseases

X Zhang, L Gao, H Meng, A Zhang, Y Liang… - Obesity …, 2023 - Wiley Online Library
Obesity is characterized by chronic low‐grade inflammation and is strongly associated with
multiple immunological diseases, including cancer and inflammatory diseases. Recent …

The onset, development and pathogenesis of severe neutrophilic asthma

X Zhang, Z Xu, X Wen, G Huang, S Nian… - … and Cell Biology, 2022 - Wiley Online Library
Bronchial asthma is divided into Th2 high, Th2 low and mixed types. The Th2 high type is
dominated by eosinophils while the Th2 low type is divided into neutrophilic and …

Apigenin ameliorates non-eosinophilic inflammation, dysregulated immune homeostasis and mitochondria-mediated airway epithelial cell apoptosis in chronic obese …

H Yu, X Huang, HH Zhu, N Wang, C Xie, YL Zhou… - Phytomedicine, 2023 - Elsevier
Background Obese asthma is one of the important asthma phenotypes that have received
wide attention in recent years. Excessive oxidative stress and different inflammatory …

The anti-inflammatory and anti-pruritus mechanisms of Huanglian Jiedu decoction in the treatment of atopic dermatitis

Y Xu, S Chen, L Zhang, G Chen, J Chen - Frontiers in pharmacology, 2021 - frontiersin.org
Atopic dermatitis (AD) is a common chronic skin disease driven by a T-cell-mediated
immune response, with inflammation and pruritus being its main clinical manifestations …

Obesity increases airway smooth muscle responses to contractile agonists

S Orfanos, J Jude, BT Deeney, G Cao… - … of Physiology-Lung …, 2018 - journals.physiology.org
The asthma-obesity syndrome represents a major public health concern that
disproportionately contributes to asthma severity and induces insensitivity to therapy. To …