Relationship between inflammatory-related cytokines with aortic dissection

J Song, H Peng, M Lai, H Kang, X Chen… - International …, 2023 - Elsevier
Aortic dissection, characterized by severe intramural hematoma formation and acute
endometrial rupture, is caused by excessive bleeding within the aortic wall or a severe tear …

Preoperative acute lung injury and oxygenation impairment occurred in the patients with acute aortic dissection

X Zhao, M Bie - BMC Cardiovascular Disorders, 2022 - Springer
Acute lung injury (ALI) and oxygenation impairment (OI) frequently occur in the patients with
acute aortic dissection (AAD), which may necessitate mechanical ventilation and result in …

Are losartan and imatinib effective against SARS-CoV2 pathogenesis? A pathophysiologic-based in silico study

R Nejat, AS Sadr - In Silico Pharmacology, 2020 - Springer
Proposing a theory about the pathophysiology of cytokine storm in COVID19, we were to find
the potential drugs to treat this disease and to find any effect of these drugs on the virus …

LILRB4 knockdown inhibits aortic dissection development by regulating pyroptosis and the JAK2/STAT3 signaling pathway

J Xiong, J Ling, J Yan, Y Duan, J Yu, W Li, W Yu… - Scientific Reports, 2024 - nature.com
Aortic dissection (AD) is a life-threatening condition with a high mortality rate and without
effective pharmacological therapies. Our previous study illustrated that leukocyte …

Differential expression profile of plasma exosomal microRNAs in acute type A aortic dissection with acute lung injury

C Zhang, H Bai, L Zhang, Y Zhang, X Chen, R Shi… - Scientific Reports, 2022 - nature.com
MicroRNAs (miRNAs) packaged into exosomes mediate cell communication and contribute
to the pathogenesis of acute type A aortic dissection (ATAAD) with acute lung injury (ALI) …

Interleukin-22 exacerbates angiotensin II-induced hypertensive renal injury

W Wang, Y Lu, X Hu, H Li, X Li, C Xiao, T Meng… - International …, 2022 - Elsevier
Hypertensive renal injury (HRI) is a main cause of end-stage renal diseases, and CD4+ T
cells and the secreted inflammatory cytokines contribute to the progress of HRI. However …

[HTML][HTML] Upregulation of miR-222-3p alleviates the symptom of aortic dissection through targeting STAT3

T Chai, X Yang, X Zhuang, Z Qiu, H Zheng, M Cai, Y Hu… - Life Sciences, 2022 - Elsevier
Objective This study sought to investigate the differentially expressed miRNAs in Aortic
dissection (AD) and explore the downstream mechanisms in regulating AD. Methods …

Interleukin-22, a potent target for treatment of non-autoimmune diseases

Y Zheng, T Li - Human vaccines & immunotherapeutics, 2018 - Taylor & Francis
ABSTRACT Interleukin− 22 (IL-22) is a member of interleukin-10 (IL-10) family cytokines that
is produced by different types of lymphocytes included in both innate and adaptive immune …

[HTML][HTML] Corrigendum to “JAK2/STAT3 pathway was associated with the protective effects of IL-22 on aortic dissection with acute lung injury”

W Ren, Z Wang, Z Wu, Z Hu, F Dai, J Chang, B Li… - Disease …, 2019 - ncbi.nlm.nih.gov
Patients with aortic dissection (AD) may present acute lung injury (ALI), and the treatment
outcome is much severe than those with single AD [1, 2]. The concentration of serum …

Systems Biology Approaches-based Biomarkers Discovery for Acute Aortic Dissection

Q Huang, Y Ren, H Li, Y Qiao… - The Heart Surgery Forum, 2018 - journal.hsforum.com
Acute aortic dissection (AAD) faces great challenges in early diagnosis and effective drug
treatment. Recent developments in systems biology approaches allow high-throughput …