The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …

Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic
with potential antiaging and antidiabetogenic properties. It is widely consumed as a …

Although cyclic nucleotide phosphodiesterases (PDEs) were described soon after the
discovery of cAMP, their complexity and functions in signaling is only recently beginning to …

Transition metal chemistry is essential to life, where metal binding to DNA, RNA, and
proteins underpins all facets of the central dogma of biology. In this context, metals in …

Cyclic nucleotide phosphodiesterases (PDEs), which are ubiquitously distributed in
mammalian tissues, play a major role in cell signaling by hydrolyzing cAMP and cGMP. Due …

DNMDP and related compounds, or velcrins, induce complex formation between the
phosphodiesterase PDE3A and the SLFN12 protein, leading to a cytotoxic response in …

Cell signaling relies extensively on dynamic pools of redox-inactive metal ions such as
sodium, potassium, calcium and zinc, but their redox-active transition metal counterparts …

Phosphodiesterases (PDEs) comprise a large family of enzymes that catalyze the hydrolysis
of cAMP or cGMP and are implicated in various diseases. We describe the high-resolution …

Methylxanthines are a group of phytochemicals derived from the purine base xanthine and
obtained from plant secondary metabolism. They are unobtrusively included in daily diet in …

Phosphodiesterases (PDEs) are essential regulators of cyclic nucleotide signaling with
diverse physiological functions. Because of their great market potential and therapeutic …