Inorganic polyphosphate in host and microbe biology

MQ Bowlin, MJ Gray - Trends in microbiology, 2021 - cell.com
Inorganic polyphosphate (polyP) is produced by both bacteria and their eukaryotic hosts,
and it appears to play multiple important roles in the interactions between those organisms …

Effects of polyphosphate on leukocyte function

PM Suess - Inorganic Polyphosphates: From Basic Research to …, 2022 - Springer
Leukocytes are immune cells derived from hematopoietic stem cells of the bone marrow
which play essential roles in inflammatory and immune responses. In contrast to anucleate …

Characterization and genomic analysis of two novel psychrotolerant Acidithiobacillus ferrooxidans strains from polar and subpolar environments

C Muñoz-Villagrán, J Grossolli-Gálvez… - Frontiers in …, 2022 - frontiersin.org
The bioleaching process is carried out by aerobic acidophilic iron-oxidizing bacteria that are
mainly mesophilic or moderately thermophilic. However, many mining sites are located in …

VapC21 Toxin Contributes to Drug-Tolerance and Interacts With Non-cognate VapB32 Antitoxin in Mycobacterium tuberculosis

A Sharma, G Chattopadhyay, P Chopra… - Frontiers in …, 2020 - frontiersin.org
The prokaryotic ubiquitous Toxin-antitoxin (TA) modules encodes for a stable toxin and an
unstable antitoxin. VapBC subfamily is the most abundant Type II TA system in M …

[HTML][HTML] Platelet polyphosphate induces fibroblast chemotaxis and myofibroblast differentiation

PM Suess, SA Smith, JH Morrissey - Journal of Thrombosis and …, 2020 - Elsevier
Background Platelets secrete many pro‐wound healing molecules such as growth factors
and cytokines. We found that releasates from activated human platelets induced the …

Polyphosphate Kinase 1 Is a Pathogenesis Determinant in Enterohemorrhagic Escherichia coli O157:H7

Y Du, X Wang, Z Han, Y Hua, K Yan, B Zhang… - Frontiers in …, 2021 - frontiersin.org
The ppk1 gene encodes polyphosphate kinase (PPK1), which is the major catalytic enzyme
that Escherichia coli utilizes to synthesize inorganic polyphosphate (polyP). The aim of this …

VTC4 Polyphosphate Polymerase Knockout Increases Stress Resistance of Saccharomyces cerevisiae Cells

A Tomashevsky, E Kulakovskaya, L Trilisenko… - Biology, 2021 - mdpi.com
Simple Summary Inorganic polyphosphate, a linear polymer of orthophosphoric acid, plays
an important role in microorganisms' stress resistance. Vtc4 protein synthetizes inorganic …

Transcriptional portrait of M. bovis BCG during biofilm production shows genes differentially expressed during intercellular aggregation and substrate attachment

MA Flores-Valdez, MJ Aceves-Sánchez… - Scientific Reports, 2020 - nature.com
Mycobacterium tuberculosis and M. smegmatis form drug-tolerant biofilms through
dedicated genetic programs. In support of a stepwise process regulating biofilm production …

Discovery and antibacterial study of potential PPK1 inhibitors against uropathogenic E. coli

L Peng, L Zeng, H Jin, L Yang, Y Xiao… - Journal of enzyme …, 2020 - Taylor & Francis
Novel antibacterial agents are urgently needed to address the infections caused by multi-
drug resistant bacteria. Urinary tract infections are common infectious diseases in clinical …

Gene Regulatory Mechanism of Mycobacterium Tuberculosis during Dormancy

Y Liu, H Li, D Dai, J He, Z Liang - Current Issues in Molecular Biology, 2024 - mdpi.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) complex, is a zoonotic
disease that remains one of the leading causes of death worldwide. Latent tuberculosis …