Liver ischaemia–reperfusion injury (LIRI), a local sterile inflammatory response driven by
innate immunity, is one of the primary causes of early organ dysfunction and failure after …

Over the past few decades, mechanisms of programmed cell death have attracted the
scientific community because they are involved in diverse human diseases. Initially …

Chronic toxicity evaluations of nanotechnology-based drugs are essential to support
initiation of clinical trials. Ideally such evaluations should address the dosing strategy in …

Alcohol-related liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are the
primary causes of chronic liver disease in western countries. Liver transplantation is …

Increased hepatic ischemia-reperfusion (IR) injury in steatotic livers is a major reason for
rejecting the use of fatty livers for liver transplantation. Necroptosis is implicated in the …

Cell death is a natural process for the turnover of aged cells, but it can also arise as a result
of pathological conditions. Cell death is recognized as a key feature in both acute and …

The mechanism of nonalcoholic fatty liver susceptibility to ischemia/reperfusion (IR) injury
has not been fully clarified. Caspase 6 is a critical regulator in innate immunity and host …

Aim Hepatic ischemia reperfusion injury (HIRI) is a leading cause of mortality post liver
transplantation, hypovolemic shock and trauma. In this study, we tested, on molecular bases …

While liver transplantation remains the sole treatment option for patients with end-stage liver
disease, there are numerous limitations to liver transplantation including the scarcity of …

Non-alcoholic fatty liver disease (NAFLD) covers a spectrum of disease ranging from
steatosis to steatohepatitis (NASH) and fibrosis, but the underlying pathophysiological …