Despite being the hallmark of cancer that is responsible for the highest number of deaths,
very little is known about the biology of metastasis. Metastatic disease typically manifests …

Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-
related deaths. Yet, it remains poorly understood. The continuous evolution of cancer …

Extracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids,
RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential …

Disseminated cancer cells from primary tumours can seed in distal tissues, but may take
several years to form overt metastases, a phenomenon that is termed tumour dormancy …

Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors, but only a
small subset of these cells generates metastases. We conducted an in vivo genome-wide …

Matrix metalloproteinases (MMPs) participate from the initial phases of cancer onset to the
settlement of a metastatic niche in a second organ. Their role in cancer progression is …

Advances in the enrichment and analysis of rare cells from the bloodstream have allowed for
detection and characterization of circulating tumor cells (CTCs) from patients with cancer …

Background: Ribociclib has demonstrated a statistically significant overall survival benefit in
pre-and postmenopausal patients with hormone receptor positive/human epidermal growth …

The concept that the pattern of metastatic spread of cancer is not random and that cancer
cells exhibit preferences when metastasizing to organs, dates back to 1889 when Steven …

Epithelial/mesenchymal transition (EMT) has emerged as a key regulator of metastasis by
facilitating tumor cell invasion and dissemination to distant organs. Recent evidences …