The helix-loop-helix (HLH) family of transcriptional regulatory proteins are key players in a
wide array of developmental processes. Over 240 HLH proteins have been identified to date …

In the eukaryotic genome, the thousands of genes that encode messenger RNA are
transcribed by a molecular machine called RNA polymerase II. Analysing the distribution …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …

The chromatin architecture of eukaryotic gene promoters is generally characterized by a
nucleosome-free region (NFR) flanked by at least one H2A. Z variant nucleosome …

To investigate mechanisms by which multiple transcription factors access complex
promoters and enhancers within cellular chromatin, we have analyzed the binding of …

It has long been known that promoter DNA is converted to a nuclease-sensitive state upon
transcriptional activation. Recent findings have raised the possibility that this conversion …

Chromatin remodeling is required for efficient transcription of eukaryotic genes. In a genetic
selection for budding yeast mutants that were defective in induction of the phosphate …

Promoters play an essential role in the regulation of gene expression for fine-tuning genetic
circuits and metabolic pathways in Saccharomyces cerevisiae (S. cerevisiae). However …

Chromatin represents a repressive barrier to the process of transcription. This molecular
obstacle is a highly dynamic structure, able to compact the DNA of the entire genome into …

In vivo footprinting studies have shown that transcription factor binding sites for HNF3 and
GATA-4 are occupied on the albumin gene enhancer in embryonic endoderm, prior to the …