The amphipathic nature of the lipid molecule (hydrophilic head and hydrophobic tails)
enables it to act as a barrier between fluids with various properties and to sustain an …

Cellular membranes comprise hundreds of lipids in which protein complexes, such as ion
channels, receptors, and scaffolding complexes, are embedded. These protein assemblies …

Ionotropic glutamate receptors are ligand-gated ion channels that mediate excitatory
synaptic transmission in the vertebrate brain. To gain a better understanding of how …

While it is known that lipids play an essential role in regulating membrane protein structure
and function, it remains challenging to identify specific protein–lipid interactions. Here, we …

Lipids in the biological membrane can modulate the structure and function of integral and
peripheral membrane proteins. Distinguishing individual lipids that bind selectively to …

Cell membranes actively participate in the regulation of protein structure and function. In this
work, we conduct molecular dynamics simulations to investigate how different membrane …

A structure of the murine voltage-dependent anion channel (VDAC) was determined by
microcrystal electron diffraction (MicroED). Microcrystals of an essential mutant of VDAC …

Spatial and temporal organization of signal transduction is coordinated through the
segregation of signaling enzymes in selected cellular compartments. This highly evolved …

Cellular membranes belong to the most vital yet least understood biomaterials of live matter.
For instance, its biomechanical requirements substantially vary across species and …

Biomembranes separate a live cell from its environment and keep it in an off-equilibrium,
steady state. They contain both phospholipids and nonphospholipids, depending on …