Brain tumors are particularly challenging malignancies, due to their location in a structurally
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …

Purpose Six years ago, in 2015, the Focused Ultrasound Foundation sponsored a workshop
to discuss, and subsequently transition the landscape, of focused ultrasound as a new …

An emerging approach with potential in improving the treatment of neurodegenerative
diseases and brain tumors is the use of focused ultrasound (FUS) to bypass the blood–brain …

While immunotherapy has emerged as a promising strategy to treat glioblastoma multiforme
(GBM), the limited availability of immunotherapeutic agents in tumors due to the presence of …

Though surgical biopsies provide direct access to tissue for genomic characterization of
brain cancer, they are invasive and pose significant clinical risks. Brain cancer management …

Survival outcomes for patients with glioblastoma multiforme (GBM) have remained poor for
the past 15 years, reflecting a clear challenge in the development of more effective treatment …

The therapeutic management of gliomas remains particularly challenging. Brain tumors
present multiple obstacles that make therapeutic innovation complex, mainly due to the …

Even though the last decade has seen a surge in the identification of molecular targets and
targeted therapies in pediatric brain tumors, the blood brain barrier (BBB) remains a …

Radiotherapy (RT) is a cornerstone treatment strategy for brain tumours. Besides
cytotoxicity, RT can cause disruption of the blood–brain barrier (BBB), resulting in an …

Abstract Diffuse Intrinsic Pontine Glioma (DIPG), now known as Diffuse Midline Glioma
(DMG) is a devastating pediatric brain tumor with limited treatment options and a very poor …