Mitochondrial dysfunction: roles in skeletal muscle atrophy

X Chen, Y Ji, R Liu, X Zhu, K Wang, X Yang… - Journal of Translational …, 2023 - Springer
Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …

Reactive oxygen species in skeletal muscle signaling

E Barbieri, P Sestili - Journal of signal transduction, 2012 - Wiley Online Library
Generation of reactive oxygen species (ROS) is a ubiquitous phenomenon in eukaryotic
cells′ life. Up to the 1990s of the past century, ROS have been solely considered as toxic …

Oxidants, antioxidants, and the beneficial roles of exercise‐induced production of reactive species

EC Gomes, AN Silva, MR Oliveira - Oxidative medicine and …, 2012 - Wiley Online Library
This review offers an overview of the influence of reactive species produced during exercise
and their effect on exercise adaptation. Reactive species and free radicals are unstable …

[HTML][HTML] Current nutritional recommendations and novel dietary strategies to manage sarcopenia

R Calvani, A Miccheli, F Landi, M Bossola… - The Journal of frailty …, 2013 - ncbi.nlm.nih.gov
Sarcopenia, the loss of skeletal muscle mass and function that occurs with aging, is
associated with increased risk for several adverse health outcomes, including frailty …

The physiopathologic role of oxidative stress in skeletal muscle

BM Scicchitano, L Pelosi, G Sica, A Musarò - Mechanisms of Ageing and …, 2018 - Elsevier
Muscle senescence is a complex mechanism that is usually associated with a decrease in
mass, strength and velocity of contraction. This state, known as sarcopenia, is a multifactorial …

The neuro-immune pathophysiology of central and peripheral fatigue in systemic immune-inflammatory and neuro-immune diseases

G Morris, M Berk, P Galecki, K Walder, M Maes - Molecular neurobiology, 2016 - Springer
Many patients with systemic immune-inflammatory and neuro-inflammatory disorders,
including depression, rheumatoid arthritis, systemic lupus erythematosus, Sjögren's disease …

Regulation of muscle atrophy in aging and disease

M Vinciguerra, A Musaro, N Rosenthal - Protein metabolism and …, 2010 - Springer
M uscle aging is characterized by a decline in functional performance and restriction of
adaptability, due to progressive loss of muscle tissue coupled with a decrease in strength …

Age-dependent alteration in muscle regeneration: the critical role of tissue niche

L Barberi, BM Scicchitano, M De Rossi, A Bigot… - Biogerontology, 2013 - Springer
Although adult skeletal muscle is composed of fully differentiated fibers, it retains the
capacity to regenerate in response to injury and to modify its contractile and metabolic …

Mitochondrial dysfunction in spinal muscular atrophy

E Zilio, V Piano, B Wirth - International Journal of Molecular Sciences, 2022 - mdpi.com
Spinal muscular atrophy (SMA) is a devastating neuromuscular disorder caused by
recessive mutations in the SMN1 gene, globally affecting~ 8–14 newborns per 100,000. The …

Efficacy of nutritional interventions as stand-alone or synergistic treatments with exercise for the management of sarcopenia

S Damanti, D Azzolino, C Roncaglione, B Arosio… - Nutrients, 2019 - mdpi.com
Sarcopenia is an age-related and accelerated process characterized by a progressive loss
of muscle mass and strength/function. It is a multifactorial process associated with several …