CRISPR-Cas for genome editing: classification, mechanism, designing and applications
S Bhatia, SK Yadav - International Journal of Biological Macromolecules, 2023 - Elsevier
Clustered regularly interspersed short pallindromic repeats (CRISPR) and CRISPR
associated proteins (Cas) system (CRISPR-Cas) came into light as prokaryotic defence …
associated proteins (Cas) system (CRISPR-Cas) came into light as prokaryotic defence …
Animal models of arrhythmia: classic electrophysiology to genetically modified large animals
S Clauss, C Bleyer, D Schuettler, P Tomsits… - Nature Reviews …, 2019 - nature.com
Arrhythmias are common and contribute substantially to cardiovascular morbidity and
mortality. The underlying pathophysiology of arrhythmias is complex and remains …
mortality. The underlying pathophysiology of arrhythmias is complex and remains …
Ex vivo cell-based CRISPR/Cas9 genome editing for therapeutic applications
The recently developed CRISPR/Cas9 technology has revolutionized the genome
engineering field. Since 2016, increasing number of studies regarding CRISPR therapeutics …
engineering field. Since 2016, increasing number of studies regarding CRISPR therapeutics …
Cardiac tissue engineering: state-of-the-art methods and outlook
AH Nguyen, P Marsh, L Schmiess-Heine… - Journal of biological …, 2019 - Springer
The purpose of this review is to assess the state-of-the-art fabrication methods, advances in
genome editing, and the use of machine learning to shape the prospective growth in cardiac …
genome editing, and the use of machine learning to shape the prospective growth in cardiac …
Non-invasive electromechanical cell-based biosensors for improved investigation of 3D cardiac models
Cardiomyocytes (CM) placed on microelectrode array (MEA) were simultaneously probed
with cantilever from atomic force microscope (AFM) system. This electric/nanomechanical …
with cantilever from atomic force microscope (AFM) system. This electric/nanomechanical …
CRISPR innovations in tissue engineering and gene editing
ZS Razavi, M Soltani, M Souri, AJ van Wijnen - Life Sciences, 2024 - Elsevier
The CRISPR/Cas9 system is a powerful tool for genome editing, utilizing the Cas9 nuclease
and programmable single guide RNA (sgRNA). However, the Cas9 nuclease activity can be …
and programmable single guide RNA (sgRNA). However, the Cas9 nuclease activity can be …
Ablation of OCT4 function in cattle embryos by double electroporation of CRISPR-Cas for DNA and RNA targeting (CRISPR-DART)
CRISPR-Cas ribonucleoproteins (RNPs) are important tools for gene editing in
preimplantation embryos. However, the inefficient production of biallelic deletions in cattle …
preimplantation embryos. However, the inefficient production of biallelic deletions in cattle …
Exosomes for CRISPR-Cas9 delivery: the cutting edge in genome editing
Gene mutation correction was challenging until the discovery of clustered regularly
interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein (Cas) …
interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein (Cas) …
New medications targeting triglyceride-rich lipoproteins: Can inhibition of ANGPTL3 or apoC-III reduce the residual cardiovascular risk?
VM Olkkonen, J Sinisalo, M Jauhiainen - Atherosclerosis, 2018 - Elsevier
Remarkably good results have been achieved in the treatment of atherosclerotic
cardiovascular diseases (CVD) by using statin, ezetimibe, antihypertensive, antithrombotic …
cardiovascular diseases (CVD) by using statin, ezetimibe, antihypertensive, antithrombotic …
Monocyte transmodulation: the next novel therapeutic approach in overcoming ischemic stroke?
J Park, JY Chang, JY Kim, JE Lee - Frontiers in neurology, 2020 - frontiersin.org
The immune response following neuroinflammation is a vital element of ischemic stroke
pathophysiology. After the onset of ischemic stroke, a specialized vasculature system that …
pathophysiology. After the onset of ischemic stroke, a specialized vasculature system that …