Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer entity characterized by a
heterogeneous genetic landscape and an immunosuppressive tumor microenvironment …

Tissue imaging has become much more colourful in the past decade. Advances in both
experimental and analytical methods now make it possible to image protein markers in …

Computational methods for integrating single-cell transcriptomic data from multiple samples
and conditions do not generally account for imbalances in the cell types measured in …

Pancreatic ductal adenocarcinoma (PDA) orchestrates a suppressive tumor
microenvironment that fosters immunotherapy resistance. Tumor-associated macrophages …

Background & Aims As pancreatic ductal adenocarcinoma (PDAC) continues to be
recalcitrant to therapeutic interventions, including poor response to immunotherapy, albeit …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy in need of new
therapeutic options. Using unbiased analyses of super-enhancers (SEs) as sentinels of core …

The efficacy of antitumor immunity is associated with the metabolic state of cytotoxic T cells,
which is sensitive to the tumor microenvironment. Whether ionic signals affect adaptive …

Desmoplastic reaction is a fibrosis reaction that is characterized by a large amount of dense
extracellular matrix (ECM) and dense fibrous stroma. Fibrotic stroma around the tumor has …

Simple Summary Pancreatic cancer is a very deadly form of cancer with a low survival rate.
One important characteristic of pancreatic cancer is the presence of a dense tissue called …

Oncogenesis and progression of pancreatic ductal adenocarcinoma (PDAC) are driven by
complex interactions between the neoplastic component and the tumor microenvironment …