Abstract MicroRNAs (miRNAs), short, highly conserved non-coding RNA, influence gene
expression by sequential mechanisms such as mRNA breakdown or translational …

Resistance to chemo-and radiotherapy is a common event among cancer patients and a
reason why new cancer therapies and therapeutic strategies need to be in continuous …

Human cancers are characterized by a number of hallmarks, including sustained
proliferative signaling, evasion of growth suppressors, activated invasion and metastasis …

MicroRNA (miRNA or miR) therapeutics in cancer are based on targeting or mimicking
miRNAs involved in cancer onset, progression, angiogenesis, epithelial-mesenchymal …

Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disorder
affecting motor neurons (MNs). Evidences indicate that ALS is a non-cell autonomous …

MicroRNAs (miRs) are potential therapeutic targets in glioblastoma multiforme (GBM), but
the difficulties associated with their delivery to tumor target cells have hampered their …

Introduction Altered epigenetic map is frequently observed in cancer and recent
investigations have demonstrated a pertinent role of epigenetic modifications in the …

Lung cancer is a commonly diagnosed cancer and the leading cause of cancer-related
deaths, posing a serious health risk. Despite new advances in immune checkpoint and …

Abstract Background/Aims: Doxorubicin (DOX) is a widely used chemotherapeutic agent for
colorectal cancer (CRC). However, the acquirement of DOX resistance limits its clinical …

Osteosarcoma (OS) is the most common type of bone sarcoma. Despite the availability of
multimodal treatment with surgery and chemotherapy, the clinical results remain …