Hepatocellular carcinoma (HCC) arises from hepatocytes through the sequential
accumulation of multiple genomic and epigenomic alterations resulting from Darwinian …

Liver cancer is the fifth most common cancer and the second most frequent cause of cancer-
related death globally. Hepatocellular carcinoma represents about 90% of primary liver …

Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer, both at the molecular
and histological level. High-throughput sequencing and gene expression profiling have …

Primary liver cancer is the second leading cause of cancer-related death worldwide and
therefore a major public health challenge. We review hypotheses of the cell of origin of liver …

Evidence-based management of patients with hepatocellular carcinoma (HCC) is key to
their optimal care. For individuals at risk for HCC, surveillance usually involves …

Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its
mortality has increased in Western populations, with a minority of patients diagnosed at …

Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a tumour that exhibits both
hepatocytic and biliary differentiation. Classical risk factors for hepatocellular carcinoma …

Percutaneous treatment of hepatocellular carcinoma (HCC) encompasses a vast range of
techniques, including monopolar radiofrequency ablation (RFA), multibipolar RFA …

Transforming growth factor-β (TGF-β) is a cytokine essential for the induction of the fibrotic
response and for the activation of the cancer stroma. Strong evidence suggests that a strong …

International Liver Cancer Association (ILCA) White Paper on Biomarker Development for
Hepatocellular Carcinoma Page 1 1 International Liver Cancer Association (ILCA) White Paper …