The discovery of the nitric oxide/cGMP pathway was the basis for our understanding of many
normal physiological functions and the pathophysiology of several diseases. Since the …

Nitric oxide (NO) is recognized as a mediator and regulator of inflammatory responses. It
possesses cytotoxic properties that are aimed against pathogenic microbes, but it can also …

Erection is basically a spinal reflex that can be initiated by recruitment of penile afferents,
both autonomic and somatic, and supraspinal influences from visual, olfactory, and …

Over the past few years, a wealth of biochemical and functional data have been gathered on
mammalian cGMP-dependent protein kinases (cGKs). In mammals, three different kinases …

Erectile dysfunction (ED) is defined as the inability of the male to attain and maintain
erection of penis sufficient to permit satisfactory sexual intercourse. Prevalence of impotence …

The purpose of this review is to provide an account of the physiological substrates of cAMP-
dependent protein kinase (PKA). Discussion is limited to just over 100 unique gene products …

In the penis, nitric oxide (NO) can be formed by both neuronal NO synthase and endothelial
NOS (eNOS). eNOS is activated by viscous drag/shear stress in blood vessels to produce …

Objectives: The goal of this study was to determine whether patients with vascular erectile
dysfunction (ED) and no other clinical cardiovascular disease have structural and functional …

Signaling cascades initiated by nitric oxide (NO) and natriuretic peptides (NPs) play an
important role in the maintenance of cardiovascular homeostasis. It is currently accepted that …

defects, desensitization, or other aberrations in the pathways distal to NO/NPs must be
recognized as capable of derailing the desired procession of events. The ensuing …