Illuminating the precise stepwise genetic programs directing cardiac development provides
insights into the mechanisms of congenital heart disease and strategies for cardiac …

Background Understanding gene regulatory networks (GRNs) is essential for unraveling the
molecular mechanisms governing cellular behavior. With the advent of high-throughput …

Background Atrial fibrillation (AF) poses a major risk for heart failure, myocardial infarction,
and stroke. Several studies have linked SCN5A variants to AF, but their precise mechanistic …

The availability of large-scale epigenomic data from various cell types and conditions has
yielded valuable insights for evaluating and learning features predicting the co-binding of …

Regulation of gene expression has recently been complexified by the identification of
Epromoters, a subset of promoters with enhancer function. Here, we uncovered the first dual …

Background Congenital heart disease (CHD) is a common birth defect, and is frequently
accompanied with extracardiac malformations (ECM). Uncovering the genetic etiology of …

Desmin related myopathy, or desminopathy, is a rare genetic disorder caused by mutations
in the intermediate filament desmin. Desmin interconnects several components of the cell …

Mutations within the DMD gene are responsible for the severe, X-linked inherited disease
Duchenne muscular dystrophy (DMD). DMD is characterised by the absence of the …