Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …

The AKT/mammalian target of rapamycin (AKT/mTOR) and ERK MAPK signaling pathways
have been shown to cooperate in prostate cancer progression and the transition to …

Increased de novo fatty acid (FA) synthesis is one hallmark of tumor cells, including prostate
cancer. We present here our most recent results showing that lipid composition in human …

A large number of novel therapeutics is currently undergoing clinical evaluation for the
treatment of prostate cancer, and small molecule signal transduction inhibitors are a …

We studied human cancer cell models in which we detected constitutive activation of ERK. A
fraction of active ERK was found to be located in mitochondria in RWPE-2 cells, obtained by …

Epidemiologic and case control population based studies over the past few decades have
identified diet as an important determinant of cancer risk. This evidence has kindled interest …

Objective We critically evaluated the etiologic role of inorganic arsenic in human prostate
cancer. Data sources We assessed data from relevant epidemiologic studies concerning …

Activation of signal transduction kinase cascades is known to alter androgen receptor (AR)
activity, but the molecular mechanisms are still poorly defined. Here we show that stress …

Regulation of the androgen receptor (AR) by its cognate ligand is well established, but how
post-translational modification modulates AR activity is only emerging. The AR is subject to …