Type I interferon (IFN) pathway dysregulation plays a crucial role in the pathogenesis of
several systemic autoimmune rheumatic diseases (SARDs), including systemic lupus …

ABSTRACT Introduction Primary Sjögren's syndrome (pSS) is a chronic autoimmune
disease standing in the crossroads of autoimmunity and lymphomagenesis, characterized …

Objective Identify autoantibodies in anti-Ro/SS-A negative primary Sjögren's syndrome (SS).
Methods This is a proof-of-concept, case-control study of SS, healthy (HC) and other disease …

Until the etiopathogenic factor (s) of autoimmune and autoinflammatory rheumatic disorders
will be identified, their classification into entities will continue. However, their similar clinical …

Interferon-alpha regulates expression of lncRNA MALAT1 and interferon-stimulated genes, as
well as chemokine production, in prim Page 1 Clinical and Experimental Rheumatology 2018 …

Background Sjögren's Syndrome (SS) is also known as autoimmune exocrine gland
disease. Previous studies have confirmed that adaptive immunity plays an important role in …

Objective The absence of CD28 is a feature of antigen-experienced, highly differentiated
and aged T cells. The pathogenicity of CD28 null T cells remains elusive in primary …

Background: Alterations of the insulin-like growth factor (IGF) pathway along with genetic
variations of the IGF1 receptor (IGF1R) gene have been linked to the development of …

Background: Sjögren's disease (SjD) is a common systemic autoimmune disease that affects
mainly women. Key pathologic features include the infiltration of exocrine glands by …

Among other systemic autoimmune diseases, primary Sjögren syndrome (pSS) bears the
highest risk for lymphoma development. In pSS, chronic antigenic stimulation gradually …