Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

Ribosomes play a pivotal role in the molecular life of every cell. Moreover, synthesis of
ribosomes is one of the most energetically demanding of all cellular processes. In eukaryotic …

Ribosome synthesis is a highly complex and coordinated process that occurs not only in the
nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells. Based on the …

The presence of a distinct nucleus, the compartment for confining the genome, transcription
and RNA maturation, is a central (and eponymous) feature that distinguishes eukaryotes …

The 5′‐exonuclease Rat1 degrades pre‐rRNA spacer fragments and processes the 5′‐
ends of the 5.8 S and 25S rRNAs. UV crosslinking revealed multiple Rat1‐binding sites …

The 90S preribosomal particle is required for the production of the 18S rRNA from a pre-
rRNA precursor. Despite the identification of the protein components of this particle, its …

We have developed a general probabilistic system for query-based discovery of pathway-
specific networks through integration of diverse genome-wide data. This framework was …

Related exosome complexes of 3′→ 5′ exonucleases are present in the nucleus and the
cytoplasm. Purification of exosome complexes from whole-cell lysates identified a Mg 2+ …

Protein synthesis on ribosomes is carefully quality-controlled to ensure the faithful
transmission of genetic information from mRNA to protein. Many of these mechanisms rely …

Ribosome is responsible for protein synthesis in all organisms and ribosomal proteins (RPs)
play important roles in the formation of a functional ribosome. L11 was recently shown to …