For nearly 50 years the proximal tubule (PT) has been known to reabsorb, process, and
either catabolize or transcytose albumin from the glomerular filtrate. Innovative techniques …

Endothelial cells (ECs) that reside on the surface of blood vessels are constantly exposed to
mechanical stimulation, including shear stress. Fluid shear stress (FSS) controls multiple …

The kidney proximal tubule is the primary site for solute reabsorption, secretion and where
kidney diseases can originate, including drug-induced toxicity. Two-dimensional cell culture …

The kidney proximal tubule (PT) elaborates a uniquely high-capacity apical endocytic
pathway to retrieve albumin and other proteins that escape the glomerular filtration barrier …

Proximal tubule (PT) cells retrieve albumin and a broad array of other ligands from the
glomerular ultrafiltrate. Efficient uptake of albumin requires PT expression of both megalin …

The multiligand receptors megalin (Lrp2) and cubilin (Cubn) and their endocytic adaptor
protein Dab2 (Dab2) play essential roles in maintaining the integrity of the apical endocytic …

Background Loss of function of the 2Cl−/H+ antiporter ClC-5 in Dent disease impairs the
uptake of filtered proteins by the kidney proximal tubule, resulting in tubular proteinuria …

Recent studies indicate that filtered albumin is retrieved in the proximal tubule (PT) via three
pathways: receptor‐mediated endocytosis via cubilin (high affinity) and megalin (low …

Beyond glycemic control, SGLT2 inhibitors (SGLT2i) have protective effects on cardiorenal
function. Renoprotection has been suggested to involve inhibition of NHE3 leading to …

The kidney proximal tubule (PT) efficiently recovers the low level of albumin and other
proteins that normally escape the glomerular filtration barrier. Two large receptors, megalin …