The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy

A Iorga, CM Cunningham, S Moazeni… - Biology of sex …, 2017 - Springer
Epidemiologic studies have previously suggested that premenopausal females have
reduced incidence of cardiovascular disease (CVD) when compared to age-matched males …

A framework for developing sex-specific engineered heart models

R Lock, H Al Asafen, S Fleischer, M Tamargo… - Nature Reviews …, 2022 - nature.com
The convergence of tissue engineering and patient-specific stem cell biology has enabled
the engineering of in vitro tissue models that allow the study of patient-tailored treatment …

Estrogen signaling as a bridge between the nucleus and mitochondria in cardiovascular diseases

E Guajardo-Correa, JF Silva-Agüero, X Calle… - Frontiers in Cell and …, 2022 - frontiersin.org
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide.
Epidemiological studies indicate that pre-menopausal women are more protected against …

Amifostine pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting apoptosis and oxidative stress

S Wu, L Tao, J Wang, Z Xu, J Wang… - Oxidative Medicine …, 2017 - Wiley Online Library
The present study was aimed at investigating the effect of amifostine on myocardial
ischemia/reperfusion (I/R) injury of mice and H9c2 cells cultured with TBHP (tert‐butyl …

When the female heart stops: sex and gender differences in out-of-hospital cardiac arrest epidemiology and resuscitation

AF Jarman, BE Mumma, SM Perman, P Kotini-Shah… - Clinical …, 2019 - Elsevier
Sex-and gender-based differences are emerging as clinically significant in the epidemiology
and resuscitation of patients with out-of-hospital cardiac arrest (OHCA). Female patients …

Sex differences in right ventricular adaptation to pressure overload in a rat model

TC Cheng, DM Tabima, LR Caggiano… - Journal of Applied …, 2022 - journals.physiology.org
With severe right ventricular (RV) pressure overload, women demonstrate better clinical
outcomes compared with men. The mechanoenergetic mechanisms underlying this …

[HTML][HTML] Divergent effects of cyclophilin-D inhibition on the female rat heart: Acute versus chronic post-myocardial infarction

RM Parodi-Rullán, J Soto-Prado, J Vega-Lugo… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: The mitochondrial permeability transition pore opening plays a critical
role in the pathogenesis of myocardial infarction. Inhibition of cyclophilin-D (CyP-D), a key …

Endurance training restores spatially distinct cardiac mitochondrial function and myocardial contractility in ovariectomized rats

EA Morra, PL Rodrigues, ICG de Jesus… - Free Radical Biology …, 2019 - Elsevier
We previously demonstrated that the loss of female hormones induces cardiac and
mitochondrial dysfunction in the female heart. Here, we show the impact of endurance …

Sex-Related Pathophysiological Differences in Cardiac Mitochondria: Role of Estrogens

N Pavón, F Correa-Segura, E Lira-Silva… - Sex Differences in Heart …, 2020 - Springer
A higher prevalence of cardiovascular diseases has been observed for long time in men;
although initially associated with stressful working situations that women supposedly did not …

Sex Differences in Ischemia-Reperfusion Injury and Cardioprotection-Revisited: The Role of S-nitrosoglutathione Reductase, S-nitrosylation, and Formaldehyde …

KM Casin - 2019 - search.proquest.com
Myocardial infarction, which can be caused by coronary artery occlusions, and the
subsequent treatment that restores blood flow (ie reperfusion) induces significant myocardial …