Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family
includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL …

Abstract Interleukin 17 (IL-17) includes several cytokines among which IL-17A is considered
as one of the major pro-inflammatory cytokine being central to the innate and adaptive …

Abstract Interleukin 37 (IL-37) and IL-1R8 (SIGIRR or TIR8) are anti-inflammatory orphan
members of the IL-1 ligand family and IL-1 receptor family, respectively. Here we …

Over recent years it has become increasingly clear that innate immune responses can
shape the adaptive immune response. Among the most potent molecules of the innate …

The commensal fungus Candida albicans causes oropharyngeal candidiasis (OPC; thrush)
in settings of immunodeficiency. Although disseminated, vaginal, and oral candidiasis are all …

Respiratory fungal infection is a severe clinical problem, especially in patients with
compromised immune functions. Aspergillus, Cryptococcus, Pneumocystis, and endemic …

Dysregulated inflammasome activation contributes to respiratory infections and pathologic
airway inflammation. Through basic and translational approaches involving murine models …

C-type lectin receptors (CLRs) comprise a heterogeneous group of transmembrane proteins.
Many of them are expressed in myeloid cells and signal in response to pathogen-derived or …

The mammalian immune system is intricately regulated, allowing for potent pathogen‐
specific immunity to be rapidly activated in response to infection with a broad and diverse …

Immune suppression increases the incidence of invasive fungal infections, particularly those
caused by the opportunistic mold Aspergillus fumigatus. Previous investigations revealed …