In the last 10 years, homocysteine has been regarded as a marker of cardiovascular disease
and a definite risk factor for many other diseases. Homocysteine is biosynthesized from …

Homocysteine (Hcy) is a sulfhydryl-containing amino acid, and intermediate metabolite
formed in metabolising methionine (Met) to cysteine (Cys); defective Met metabolism can …

Background Methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C and methionine
synthase reductase (MTRR) A66G polymorphisms are important genetic determinants for …

Folate deficiency is strongly associated with cardiovascular disease. We aimed to explore
the joint effect of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C …

Background The geographical and ethnic distributions of the polymorphic
methylenetetrahydrofolate reductase (MTHFR) mutations (C677T and A1298C) and …

Chronic kidney disease (CKD) is an increasing health care problem. About 10% of the
general population is affected by CKD, representing the sixth cause of death in the world …

Background Dyslipidemia is a well-established risk factor for cardiovascular disease. Serum
lipids were affected by several gene polymorphisms, folate, homocysteine and other …

We aimed to investigate the joint effect of homocysteine metabolism gene polymorphisms,
as well as the folate deficiency on the risk of HHcy in a Chinese hypertensive population …

Background Folate plays a pivotal role in DNA synthesis, repair, methylation and
homocysteine (Hcy) metabolism. Therefore, alterations in the folate-mediated one-carbon …

3-Mercaptopyruvate sulfurtransferase (3MST) is an important enzyme for the synthesis of
hydrogen sulfide (H2S) in the brain. We present here data that indicate an exclusively …