Extracellular vesicles in immunomodulation and tumor progression

C Marar, B Starich, D Wirtz - Nature immunology, 2021 - nature.com
Extracellular vesicles have emerged as prominent regulators of the immune response
during tumor progression. EVs contain a diverse repertoire of molecular cargo that plays a …

RNA delivery by extracellular vesicles in mammalian cells and its applications

K O'Brien, K Breyne, S Ughetto, LC Laurent… - … reviews Molecular cell …, 2020 - nature.com
The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

JA Welsh, DCI Goberdhan, L O'Driscoll… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of
origin and change the functions and phenotypes of other cells. These features indicate …

Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker

FG Kugeratski, K Hodge, S Lilla, KM McAndrews… - Nature cell …, 2021 - nature.com
Exosomes are extracellular vesicles derived from the endosomal compartment that are
potentially involved in intercellular communication. Here, we found that frequently used …

Biodistribution of extracellular vesicles following administration into animals: A systematic review

M Kang, V Jordan, C Blenkiron… - Journal of extracellular …, 2021 - Wiley Online Library
In recent years, attention has turned to examining the biodistribution of EVs in recipient
animals to bridge between knowledge of EV function in vitro and in vivo. We undertook a …

Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy

J Wang, W Tang, M Yang, Y Yin, H Li, F Hu, L Tang… - Biomaterials, 2021 - Elsevier
Clinical treatment of malignant glioma remains a major challenge due to high infiltrative
growth and chemotherapeutic resistance of tumors and the presence of the blood brain …

Extracellular vesicle heterogeneity: subpopulations, isolation techniques, and diverse functions in cancer progression

E Willms, C Cabañas, I Mäger, MJA Wood… - Frontiers in …, 2018 - frontiersin.org
Cells release membrane enclosed nano-sized vesicles termed extracellular vesicles (EVs)
that function as mediators of intercellular communication by transferring biological …

Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT

X Zhang, B Sai, F Wang, L Wang, Y Wang, L Zheng… - Molecular cancer, 2019 - Springer
Background Metastasis is the main cause of lung cancer mortality. Bone marrow-derived
mesenchymal stem cells (BMSCs) are a component of the cancer microenvironment and …

Isolation and characterization of exosomes for cancer research

L Zhu, HT Sun, S Wang, SL Huang, Y Zheng… - Journal of hematology & …, 2020 - Springer
Exosomes are a subset of extracellular vesicles that carry specific combinations of proteins,
nucleic acids, metabolites, and lipids. Mounting evidence suggests that exosomes …

Potential use of exosomes as diagnostic biomarkers and in targeted drug delivery: progress in clinical and preclinical applications

MN Huda, M Nafiujjaman, IG Deaguero… - ACS biomaterials …, 2021 - ACS Publications
Exosomes are cell-derived vesicles containing heterogeneous active biomolecules such as
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …