Metastatic osteosarcoma: a challenging multidisciplinary treatment

C Meazza, P Scanagatta - Expert review of anticancer therapy, 2016 - Taylor & Francis
Osteosarcoma is the most common malignant bone tumor, currently treated with pre-and
postoperative chemotherapy in association with the surgical removal of the tumor. About 15 …

Origin and therapies of osteosarcoma

B Moukengue, M Lallier, L Marchandet, M Baud'huin… - Cancers, 2022 - mdpi.com
Simple Summary Osteosarcoma is the most common malignant bone tumor in children, with
a 5-year survival rate ranging from 70% to 20% depending on the aggressiveness of the …

Mechanisms of resistance to conventional therapies for osteosarcoma

L Marchandet, M Lallier, C Charrier, M Baud'huin… - Cancers, 2021 - mdpi.com
Simple Summary Osteosarcoma (OS), the most common primary bone tumor, mainly affects
children and adolescents. Unfortunately, in some cases, the absence of response to …

Bioceramics for drug delivery

D Arcos, M Vallet-Regi - Acta Materialia, 2013 - Elsevier
Bioceramics, such as calcium phosphate ceramics and cements and silica-based glasses,
are widely used as components of implants for bone and teeth restoration. Nowadays, the …

Current therapeutic strategies and novel approaches in osteosarcoma

K Ando, MF Heymann, V Stresing, K Mori, F Rédini… - Cancers, 2013 - mdpi.com
Osteosarcoma is the most frequent malignant primary bone tumor and a main cause of
cancer-related death in children and adolescents. Although long-term survival in localized …

KLF4 functions as an oncogene in promoting cancer stem cell-like characteristics in osteosarcoma cells

X Qi, Y Li, Y Zhang, T Xu, B Lu, L Fang, J Gao… - Acta Pharmacologica …, 2019 - nature.com
Despite more effective chemotherapy combined with limb-salvage surgery for the
osteosarcoma treatment, survival rates for osteosarcoma patients have stagnated over the …

Roles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair

CE Macsai, BK Foster, CJ Xian - Journal of cellular physiology, 2008 - Wiley Online Library
Wnt signalling has an essential role in regulating bone formation and remodelling during
embryonic development and throughout postnatal and adult life. Specifically, Wnt signalling …

[HTML][HTML] Role of MTH1 in oxidative stress and therapeutic targeting of cancer

A Taiyab, A Ashraf, MN Sulaimani, A Rathi, A Shamsi… - Redox Biology, 2024 - Elsevier
Cancer cells maintain high levels of reactive oxygen species (ROS) to drive their growth, but
ROS can trigger cell death through oxidative stress and DNA damage. To survive enhanced …

Current status and perspectives regarding the treatment of osteosarcoma: chemotherapy

A Sakamoto, Y Iwamoto - Reviews on recent clinical trials, 2008 - ingentaconnect.com
Osteosarcoma is the most common primary bone tumor in childhood and adolescence. The
use of combination chemotherapy and surgery enables long-term survival in approximately …

[HTML][HTML] A novel circular RNA circRBMS3 regulates proliferation and metastasis of osteosarcoma by targeting miR-424-eIF4B/YRDC axis

Z Gong, P Shen, H Wang, J Zhu, K Liang… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Circular RNAs (circRNAs) have been demonstrated to have critical regulatory roles in
tumorigenesis. However, the contribution of circRNAs to OS (osteosarcoma) remains largely …