Naturally acquired immunity to falciparum malaria protects millions of people routinely
exposed to Plasmodium falciparum infection from severe disease and death. There is no …

Throughout history malaria has proved to be a significant threat to human health. Between
300 and 500 million clinical cases occur each year worldwide, approximately 2 million of …

A major change in recent years has been the recognition that severe malaria, predominantly
caused by Plasmodium falciparum, is a complex multi-system disorder presenting with a …

Background The ability of T cells, acting independently of antibodies, to control malaria
parasite growth in people has not been defined. If such cell-mediated immunity was shown …

Understanding the targets and mechanisms of human immunity to malaria caused by
Plasmodium falciparum is crucial for advancing effective vaccines and developing tools for …

To determine the potential contribution of innate immune responses to the early
proinflammatory cytokine response to Plasmodium falciparum malaria, we have examined …

Background Animal models with various combination of host-parasite have long been
employed to study malaria pathogenesis. Here, we describe the combination of Plasmodium …

The role of endogenous gamma interferon (IFN-γ) in protective immunity against blood-
stage Plasmodium chabaudi AS malaria was studied using IFN-γ gene knockout (GKO) and …

The relationship between malaria-related outcomes and cytokine production in whole blood
cultures associated with cellular immune responses and immunity to Plasmodium falciparum …

Malaria is still a major cause of severe disease which is responsible for millions of deaths,
mostly in children under 5 years old, in tropical countries, especially sub-Saharan Africa …