The intestinal tract faces numerous challenges that require several layers of defence. The
tight epithelium forms a physical barrier that is further protected by a mucus layer, which …

The intestinal epithelial barrier (IEB) is one of the largest interfaces between the
environment and the internal milieu of the body. It is essential to limit the passage of harmful …

The human gastrointestinal (GI) tract harbours a complex and dynamic population of
microorganisms, the gut microbiota, which exert a marked influence on the host during …

The intestinal tract is inhabited by a tremendous number of microorganisms, termed the gut
microbiota. These microorganisms live in a mutualistic relationship with their host and assist …

The largest surface of the human body exposed to the external environment is the gut. At this
level, the intestinal barrier includes luminal microbes, the mucin layer, gastrointestinal …

A number of mechanisms ensure that the intestine is protected from pathogens and also
against our own intestinal microbiota. The outermost of these is the secreted mucus, which …

Objective The colonic inner mucus layer protects us from pathogens and commensal-
induced inflammation, and has been shown to be defective in active UC. The aim of this …

The emerging evidence on the interconnectedness between the gut microbiome and host
metabolism has led to a paradigm shift in the study of metabolic diseases such as obesity …

The gut barrier plays a crucial role by spatially compartmentalizing bacteria to the lumen
through the production of secreted mucus and is fortified by the production of secretory IgA …

The abundance of innate and adaptive immune cells that reside together with trillions of
beneficial commensal microorganisms in the mammalian gastrointestinal tract requires …