Simple Summary Alterations of the MEK5/ERK5 signaling pathway have been described in
several tumors, and emerging data are trying to explain the complexity of ERK5-related …

The RAS-regulated RAF-MEK1/2-ERK1/2 signalling pathway is frequently de-regulated in
human cancer. Melanoma in particular exhibits a high incidence of activating BRAFV600E/K …

The extracellular signal-regulated kinase 5 (ERK5) signaling pathway is one of four
conventional mitogen-activated protein (MAP) kinase pathways. Genetic perturbation of …

Glioblastoma is the most frequently diagnosed type of primary brain tumour in adults. These
aggressive tumours are characterised by inherent treatment resistance and disease …

Glioma stem cells (GSCs) contribute to the pathogenesis of glioblastoma, the most
malignant form of glioma. The implication and underlying mechanisms of SMAD specific E3 …

The DNA Damage Response (DDR) pathways sense DNA damage and coordinate robust
DNA repair and bypass mechanisms. A series of repair proteins are recruited depending on …

Mutated KRAS serves as the oncogenic driver in 30% of non-small cell lung cancers
(NSCLCs) and is associated with metastatic and therapy-resistant tumors. Focal Adhesion …

Glioma stem cells (GSC) promote the malignancy of glioblastoma (GBM), the most lethal
brain tumor. ERK5 belongs to the MAPK family. Here, we demonstrated that MAPK kinase 5 …

Technological advancements in the present era have enhanced drug discovery and
development. Nanomedicines are valuable pharmacotherapeutic tools against several …

Simple Summary Glioblastoma multiforme (GBM) remains to be the most frequent malignant
tumor of the central nervous system (CNS), which accounts for approximately 54% of all …